Rabbit Anti-BORA Recombinant Antibody (D2B9) (CBMAB-CP0015-LY)

Name: Rabbit Anti-BORA Recombinant Antibody (D2B9)
SKU: CBMAB-CP0015-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D2B9

Application

WB, IP, FC

Immunogen

Recombinant protein specific to the carboxy terminus of human Bora protein.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000
IP	1:50
FC	1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

BORA aurora kinase A activator

Introduction

BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).

Entrez Gene ID

79866

UniProt ID

Q6PGQ7

Alternative Names

C13orf34

Function

Required for the activation of AURKA at the onset of mitosis.

Biological Process

Activation of protein kinase activity Source: GO_Central
Cell division Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: Reactome
Regulation of mitotic nuclear division Source: UniProtKB
Regulation of mitotic spindle organization Source: UniProtKB
Regulation of protein localization Source: UniProtKB

Cellular Location

Cytosol; Nucleus; Cytoplasm

PTM

Phosphorylated by AURKA.

Mamoor, S. (2021). Over-expression of bora, aurora kinase A activator in human endometrial cancer.

Tavernier, N., Thomas, Y., Vigneron, S., Maisonneuve, P., Orlicky, S., Mader, P., ... & Pintard, L. (2021). Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry. Nature communications, 12(1), 1-22.

Parrilla, A., Barber, M., Majem, B., Castellví, J., Morote, J., Sánchez, J. L., ... & Santamaria, A. (2020). Aurora borealis (Bora), which promotes Plk1 activation by Aurora A, has an oncogenic role in ovarian cancer. Cancers, 12(4), 886.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-Bora Recombinant Antibody (CBYY-1755) (CAT#: CBMAB-2104-YY)

Mouse Anti-Bora Recombinant Antibody (CBYY-1756) (CAT#: CBMAB-2105-YY)

Mouse Anti-Bora Recombinant Antibody (CBYY-0726) (CAT#: CBMAB-0729-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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