Sign in or Register   Sign in or Register
  |  

Rabbit Anti-BPGM Recombinant Antibody (CBYY-0730) (CBMAB-0733-YY)

This product is rabbit antibody that recognizes BPGM. The antibody CBYY-0730 can be used for immunoassay techniques such as: WB
See all BPGM antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYY-0730
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.981 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
2,3-bisphosphoglycerate mutase
Introduction
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
Entrez Gene ID
669
UniProt ID
P07738
Alternative Names
Bisphosphoglycerate Mutase; 2,3-Bisphosphoglycerate Mutase, Erythrocyte; 2,3-Bisphosphoglycerate Synthase; 2,3-Diphosphoglycerate Mutase; BPG-Dependent PGAM; DPGM;
Function
Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity.
Biological Process
Carbohydrate derivative catabolic process Source: Reactome
Carbohydrate metabolic process Source: ProtInc
Erythrocyte development Source: Ensembl
Glycolytic process Source: UniProtKB-KW
Respiratory gaseous exchange by respiratory system Source: ProtInc
Cellular Location
Cytosol; Extracellular exosome
Involvement in disease
Erythrocytosis, familial, 8 (ECYT8): An autosomal recessive disorder characterized by elevated serum hemoglobin and hematocrit, and biphosphoglycerate mutase deficiency. ECYT8 affected individuals manifest hemolytic anemia and splenomegaly.
PTM
Glycation of Lys-159 in diabetic patients inactivates the enzyme.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-BPGM Recombinant Antibody (CBYY-0730)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare