Mouse Anti-BPIFA1 Recombinant Antibody (3C1) (CBMAB-P0112-YC)

Name: Mouse Anti-BPIFA1 Recombinant Antibody (3C1)
SKU: CBMAB-P0112-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3C1

Application

E, WB

Immunogen

Full length recombinant corresponding to aa1-257 from human PLUNC (AAH12549) with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Bpi Fold Containing Family A Member 1

Introduction

BPIFA1 is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known.

Entrez Gene ID

51297

UniProt ID

Q9NP55

Alternative Names

BPI Fold Containing Family A Member 1; Palate Lung And Nasal Epithelium Clone Protein; Secretory Protein In Upper Respiratory Tracts; Palate, Lung And Nasal Epithelium Associated; Nasopharyngeal Carcinoma-Related Protein; Lung-Specific Protein X; Von Ebner Protein Hl; Short PLUNC1; SPLUNC1; PLUNC; SPURT;

Function

Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608).
Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494).
Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151).
Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776).
Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234).
May attract macrophages and neutrophils (PubMed:23132494).

Biological Process

Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Defense response to virus Source: UniProtKB
Immune response in nasopharyngeal-associated lymphoid tissue Source: UniProtKB
Innate immune response Source: UniProtKB
Multicellular organismal water homeostasis Source: UniProtKB
Negative regulation of single-species biofilm formation in or on host organism Source: UniProtKB
Regulation of liquid surface tension Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: UniProtKB

Cellular Location

Secreted. Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.

PTM

May be N-glycosylated.

Zhang, R., Trower, J., & Wu, T. (2020). Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function. International journal of biological macromolecules, 164, 4022-4031.

Saferali, A., Tang, A. C., Strug, L. J., Quon, B. S., Zlosnik, J., Sandford, A. J., & Turvey, S. E. (2020). Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1. Plos one, 15(1), e0227067.

Britto, C. J., Niu, N., Khanal, S., Huleihel, L., Herazo-Maya, J. D., Thompson, A., ... & Cohn, L. E. (2019). BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation. American journal of physiology-lung cellular and molecular physiology, 316(2), L321-L333.

Khanal, S., Niu, N., Sharma, L., Liu, W., Cohn, L., Cruz, C. D., & Britto, C. (2019). BPI-fold containing Family A member 1 (Bpifa1) Role in IFN Driven Pulmonary Response.

Khanal, S., Niu, N., Huleihel, L., Herazo-Maya, J., Kaminski, N., Cohn, L., & Britto, C. (2018). BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammation.

Britto, C., Khanal, S., Wu, B., Li, Y., & Segal, L. (2018). BPI Fold Containing Family A Member 1 (BPIFA1) regulates mucosal microbiota and basal Interferon signaling.

Britto-Leon, C. J., Khanal, S., Wu, B., Li, Y., & Segal, L. N. (2018). BPI-Fold Containing Family A Member 1 (BPIFA1) Regulates Mucosal Immunity and Airway Microbiota. In D107. HOST PATHOGEN INTERACTIONS (pp. A7568-A7568). American Thoracic Society.

Wang, H., Jiang, D., Li, W., & Wang, S. (2017). Increased expression of BPI fold‑containing family A member 1 is associated with metastasis and poor prognosis in human colorectal carcinoma. Oncology letters, 14(4), 4231-4236.

Guo, Y., Guo, L. N., Zhu, J. F., Tang, C. Y., Feng, Y. Z., & Zhou, H. D. (2017). Associations of salivary BPIFA1 protein in chronic periodontitis patients with type 2 diabetes mellitus. International journal of endocrinology, 2017.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
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For research use only. Not intended for any clinical use.

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