Sign in or Register   Sign in or Register
  |  

Mouse Anti-BPIFA1 Recombinant Antibody (CBXS-5764) (CBMAB-S0624-CQ)

This product is a mouse antibody that recognizes BPIFA1. The antibody CBXS-5764 can be used for immunoassay techniques such as: FC, IA, IF.
See all BPIFA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5764
Antibody Isotype
IgG1
Application
FC, IA, IF

Basic Information

Immunogen
Recombinant SPLUNC2
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA
Preservative
0.02% sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bpi Fold Containing Family A Member 1
Entrez Gene ID
UniProt ID
Alternative Names
LUNX; NASG; PLUNC; SPLUNC1; SPURT; bA49G10.5
Function
Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608).
Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494).
Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151).
Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776).
Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234).
May attract macrophages and neutrophils (PubMed:23132494).
Biological Process
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Defense response to virus Source: UniProtKB
Immune response in nasopharyngeal-associated lymphoid tissue Source: UniProtKB
Innate immune response Source: UniProtKB
Multicellular organismal water homeostasis Source: UniProtKB
Negative regulation of single-species biofilm formation in or on host organism Source: UniProtKB
Regulation of liquid surface tension Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: UniProtKB
Cellular Location
Secreted. Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
PTM
May be N-glycosylated.

Zhang, R., Trower, J., & Wu, T. (2020). Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function. International journal of biological macromolecules, 164, 4022-4031.

Saferali, A., Tang, A. C., Strug, L. J., Quon, B. S., Zlosnik, J., Sandford, A. J., & Turvey, S. E. (2020). Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1. Plos one, 15(1), e0227067.

Britto, C. J., Niu, N., Khanal, S., Huleihel, L., Herazo-Maya, J. D., Thompson, A., ... & Cohn, L. E. (2019). BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation. American journal of physiology-lung cellular and molecular physiology, 316(2), L321-L333.

Khanal, S., Niu, N., Sharma, L., Liu, W., Cohn, L., Cruz, C. D., & Britto, C. (2019). BPI-fold containing Family A member 1 (Bpifa1) Role in IFN Driven Pulmonary Response.

Khanal, S., Niu, N., Huleihel, L., Herazo-Maya, J., Kaminski, N., Cohn, L., & Britto, C. (2018). BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammation.

Britto, C., Khanal, S., Wu, B., Li, Y., & Segal, L. (2018). BPI Fold Containing Family A Member 1 (BPIFA1) regulates mucosal microbiota and basal Interferon signaling.

Britto-Leon, C. J., Khanal, S., Wu, B., Li, Y., & Segal, L. N. (2018). BPI-Fold Containing Family A Member 1 (BPIFA1) Regulates Mucosal Immunity and Airway Microbiota. In D107. HOST PATHOGEN INTERACTIONS (pp. A7568-A7568). American Thoracic Society.

Wang, H., Jiang, D., Li, W., & Wang, S. (2017). Increased expression of BPI fold‑containing family A member 1 is associated with metastasis and poor prognosis in human colorectal carcinoma. Oncology letters, 14(4), 4231-4236.

Guo, Y., Guo, L. N., Zhu, J. F., Tang, C. Y., Feng, Y. Z., & Zhou, H. D. (2017). Associations of salivary BPIFA1 protein in chronic periodontitis patients with type 2 diabetes mellitus. International journal of endocrinology, 2017.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-BPIFA1 Recombinant Antibody (CBXS-5764)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare