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Mouse Anti-BRAP Recombinant Antibody (CB71A) (CBMAB-CA071LY)

The product is antibody recognizes BRAP. The antibody CB71A immunoassay techniques such as: ELISA, WB.
See all BRAP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CB71A
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Purified recombinant Human BRAP protein fragments expressed in E.coli.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BRCA1 Associated Protein
Introduction
The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]
Entrez Gene ID
8315
UniProt ID
Q7Z569
Alternative Names
BRCA1 Associated Protein; Impedes Mitogenic Signal Propagation; RING-Type E3 Ubiquitin Transferase BRAP2; Renal Carcinoma Antigen NY-REN-63; Galectin-2-Binding Protein; RING Finger Protein 52;
Function
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Biological Process
MAPK cascade Source: MGI
Negative regulation of signal transduction Source: UniProtKB
Protein ubiquitination Source: FlyBase
Ras protein signal transduction Source: MGI
Cellular Location
Cytoplasm

Derks, W., & Bergmann, O. (2020). BRAP: a novel regulator of the cardiomyocyte cell cycle controlling both proliferation and survival?. Cardiovascular research, 116(3), 467.

Wang, B., Cao, C., Liu, X., He, X., Zhuang, H., Wang, D., & Chen, B. (2020). BRCA1-associated protein inhibits glioma cell proliferation and migration and glioma stem cell self-renewal via the TGF-β/PI3K/AKT/mTOR signalling pathway. Cellular Oncology, 43(2), 223-235.

Ju, Q., Zhao, Y., Li, X. M., & Zhang, H. (2020). BRCA1 Associated Protein is a prognostic biomarker and correlated with immune infiltrates in liver hepatocellular carcinoma: a pan-cancer analysis. Frontiers in Molecular Biosciences, 7, 279.

Volland, C., Schott, P., Didié, M., Männer, J., Unsöld, B., Toischer, K., ... & Seidler, T. (2020). Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival. Cardiovascular research, 116(3), 592-604.

Wei, X., Liu, X., Liu, H., He, X., Zhuang, H., Tang, Y., & Wang, B. (2020). BRCA1-associated protein induced proliferation and migration of gastric cancer cells through MAPK pathway. Surgical Oncology, 35, 191-199.

Chen, I. C., Kuo, P. H., Yang, A. C., Tsai, S. J., Liu, T. H., Liu, H. J., ... & Liu, Y. L. (2020). CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption. Scientific reports, 10(1), 1-11.

Chida-Nagai, A., Shintani, M., Sato, H., Nakayama, T., Nii, M., Akagawa, H., ... & Nakanishi, T. (2019). Role of BRCA1-associated protein (BRAP) variant in childhood pulmonary arterial hypertension. PloS one, 14(1), e0211450.

Kim, J. W., Choe, Y. M., Shin, J. G., Park, B. L., Shin, H. D., Choi, I. G., & Lee, B. C. (2019). Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test. Neuropsychiatric disease and treatment, 15, 83.

Yin, W. J., Li, L. M., Wang, L., Huang, A., Qiao, A. X., Jia, Y. T., & Feng, Y. (2019). Correlation between BRAP expression and prognosis of patients with laryngeal squamous cell carcinoma. Lin Chuang er bi yan hou tou Jing wai ke za zhi= Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery, 33(11), 1081-1084.

Zhao, Y., Wei, L., Shao, M., Huang, X., Chang, J., Zheng, J., ... & Wu, C. (2017). BRCA1-associated protein increases invasiveness of esophageal squamous cell carcinoma. Gastroenterology, 153(5), 1304-1319.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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