Human BRAP ELISA Kit (V2LY-0626-LY5525)

Go to compare Compare Online Inquiry
Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.01 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
67.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
BRCA1 Associated Protein
Function
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Biological Process
MAPK cascade Source: MGI
Negative regulation of signal transduction Source: UniProtKB
Protein ubiquitination Source: FlyBase
Ras protein signal transduction Source: MGI
Cellular Location
Cytoplasm

Derks, W., & Bergmann, O. (2020). BRAP: a novel regulator of the cardiomyocyte cell cycle controlling both proliferation and survival?. Cardiovascular research, 116(3), 467.

Wang, B., Cao, C., Liu, X., He, X., Zhuang, H., Wang, D., & Chen, B. (2020). BRCA1-associated protein inhibits glioma cell proliferation and migration and glioma stem cell self-renewal via the TGF-β/PI3K/AKT/mTOR signalling pathway. Cellular Oncology, 43(2), 223-235.

Ju, Q., Zhao, Y., Li, X. M., & Zhang, H. (2020). BRCA1 Associated Protein is a prognostic biomarker and correlated with immune infiltrates in liver hepatocellular carcinoma: a pan-cancer analysis. Frontiers in Molecular Biosciences, 7, 279.

Volland, C., Schott, P., Didié, M., Männer, J., Unsöld, B., Toischer, K., ... & Seidler, T. (2020). Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival. Cardiovascular research, 116(3), 592-604.

Wei, X., Liu, X., Liu, H., He, X., Zhuang, H., Tang, Y., & Wang, B. (2020). BRCA1-associated protein induced proliferation and migration of gastric cancer cells through MAPK pathway. Surgical Oncology, 35, 191-199.

Chen, I. C., Kuo, P. H., Yang, A. C., Tsai, S. J., Liu, T. H., Liu, H. J., ... & Liu, Y. L. (2020). CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption. Scientific reports, 10(1), 1-11.

Chida-Nagai, A., Shintani, M., Sato, H., Nakayama, T., Nii, M., Akagawa, H., ... & Nakanishi, T. (2019). Role of BRCA1-associated protein (BRAP) variant in childhood pulmonary arterial hypertension. PloS one, 14(1), e0211450.

Kim, J. W., Choe, Y. M., Shin, J. G., Park, B. L., Shin, H. D., Choi, I. G., & Lee, B. C. (2019). Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test. Neuropsychiatric disease and treatment, 15, 83.

Yin, W. J., Li, L. M., Wang, L., Huang, A., Qiao, A. X., Jia, Y. T., & Feng, Y. (2019). Correlation between BRAP expression and prognosis of patients with laryngeal squamous cell carcinoma. Lin Chuang er bi yan hou tou Jing wai ke za zhi= Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery, 33(11), 1081-1084.

Zhao, Y., Wei, L., Shao, M., Huang, X., Chang, J., Zheng, J., ... & Wu, C. (2017). BRCA1-associated protein increases invasiveness of esophageal squamous cell carcinoma. Gastroenterology, 153(5), 1304-1319.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Human BRAP ELISA Kit?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.