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Mouse Anti-MPC2 Recombinant Antibody (2B2) (CBMAB-A0885-LY)

The product is antibody recognizes BRP44. The antibody 2B2 immunoassay techniques such as: ELISA.
See all MPC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B2
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
BRP44 (NP_056230, 1 a.a. ~ 127 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Mitochondrial Pyruvate Carrier 2
Entrez Gene ID
UniProt ID
Alternative Names
DKFZp564B167; MGC125752; MGC125753
Function
Mediates the uptake of pyruvate into mitochondria.
Biological Process
Nitochondrial acetyl-CoA biosynthetic process from pyruvate Source: Ensembl
Nitochondrial pyruvate transmembrane transport Source: GO_Central
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Cellular Location
Mitochondrion inner membrane

Tavoulari, S., Sichrovsky, M., & Kunji, E. R. (2023). Fifty years of the mitochondrial pyruvate carrier: New insights into its structure, function, and inhibition. Acta Physiologica, 238(4), e14016.

Pujol, C., Lebigot, E., Gaignard, P., Galai, S., Kraoua, I., Bault, J. P., ... & Slama, A. (2023). MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy. Brain, 146(3), 858-864.

Jiang, H., Alahmad, A., Fu, S., Fu, X., Liu, Z., Han, X., ... & Fang, F. (2022). Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency. Journal of Inherited Metabolic Disease, 45(2), 264-277.

Fernandez-Caggiano, M., & Eaton, P. (2021). Heart failure—Emerging roles for the mitochondrial pyruvate carrier. Cell Death & Differentiation, 28(4), 1149-1158.

Ruiz-Iglesias, A., & Mañes, S. (2021). The importance of mitochondrial pyruvate carrier in cancer cell metabolism and tumorigenesis. Cancers, 13(7), 1488.

Zangari, J., Petrelli, F., Maillot, B., & Martinou, J. C. (2020). The multifaceted pyruvate metabolism: role of the mitochondrial pyruvate carrier. Biomolecules, 10(7), 1068.

Buchanan, J. L., & Taylor, E. B. (2020). Mitochondrial pyruvate carrier function in health and disease across the lifespan. Biomolecules, 10(8), 1162.

Feng, J., Ma, Y., Chen, Z., Hu, J., Yang, Q., & Ding, G. (2019). Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes. Life sciences, 237, 116941.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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