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Mouse Anti-BRPF1 Antibody (2E11) (CBMAB-0178-YC)

Provided herein are mouse monoclonal antibodies against Human BRPF1. The antibody clone 2E11 can be used for immunoassay techniques, such as IP and MA.
See all BRPF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E11
Antibody Isotype
IgG2c
Application
IP, MA

Basic Information

Immunogen
Recombinant peptide
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BRPF1
Introduction
BRPF1 (bromodomain and PHD finger containing, 1) is a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. BRPF1 is a multivalent chromatin regulator that recognizes different epigenetic marks and may play a role in stimulating acetyltransferase and transcriptional activity of the complex.
Entrez Gene ID
7862
UniProt ID
P55201
Alternative Names
BR140
Function
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640).
Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767).
Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640).
Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358).
Biological Process
Histone H3 acetylation Source: UniProtKB
Histone H3-K14 acetylation Source: UniProtKB
Histone H3-K23 acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of signal transduction by p53 class mediator Source: Reactome
Cellular Location
Nucleus; Cytoplasm; Chromosome. Localization to the nucleus depends on KAT6A, ING5 and MEAF6 (PubMed:18794358, PubMed:27939640). Localizes to transcription start sites (PubMed:24065767).
Involvement in disease
Intellectual developmental disorder with dysmorphic facies and ptosis (IDDDFP): An autosomal dominant neurodevelopmental disorder characterized by delayed psychomotor development, intellectual disability, delayed language, and facial dysmorphisms, most notably ptosis. Additional features may include poor growth, hypotonia, and seizures.
PTM
Acetylated by KAT6A.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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