Mouse Anti-BST1 Recombinant Antibody (4C2) (CBMAB-A0891-LY)

Name: Mouse Anti-BST1 Recombinant Antibody (4C2)
SKU: CBMAB-A0891-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4C2

Application

WB, E

Immunogen

BST1 (AAH12095.1, 1 a.a. ~ 318 a.a) full-length recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Bone Marrow Stromal Cell Antigen 1

Introduction

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq]

Entrez Gene ID

683

UniProt ID

Q10588

Alternative Names

CD157

Function

Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Biological Process

Humoral immune response Source: ParkinsonsUK-UCL
NAD metabolic process Source: Reactome
Neutrophil degranulation Source: Reactome
Positive regulation of B cell proliferation Source: GO_Central
Positive regulation of cell population proliferation Source: ParkinsonsUK-UCL
Regulation of actin cytoskeleton organization Source: ParkinsonsUK-UCL
Regulation of calcium-mediated signaling Source: ParkinsonsUK-UCL
Regulation of cell-matrix adhesion Source: ParkinsonsUK-UCL
Regulation of cellular extravasation Source: ParkinsonsUK-UCL
Regulation of inflammatory response Source: ParkinsonsUK-UCL
Regulation of integrin-mediated signaling pathway Source: ParkinsonsUK-UCL
Regulation of neutrophil chemotaxis Source: ParkinsonsUK-UCL
Regulation of peptidyl-tyrosine phosphorylation Source: ParkinsonsUK-UCL
Regulation of superoxide metabolic process Source: ParkinsonsUK-UCL
Signal transduction Source: ParkinsonsUK-UCL

Cellular Location

Cell membrane

Ishihara, K., Yahagi, A., Katsumata, R., Shiotani, A., & Iseki, M. (2021). Lack of bone marrow stromal cell antigen-1 (BST-1)/CD157 ameliorated colitis induced by dextran sodium sulfate (DSS).

Shen, Y. T., Wang, J. W., Wang, M., Zhi, Y., Li, J. Y., Yuan, Y. S., ... & Zhang, K. Z. (2019). BST1 rs4698412 allelic variant increases the risk of gait or balance deficits in patients with Parkinson’s disease. CNS neuroscience & therapeutics, 25(4), 422-429.

Damavandi, M. D., Vlachogiannis, G., Nyamundanda, G., Lampis, A., Hedayat, S., Parkes, H., ... & Valeri, N. (2018). PO-346 Defining microRNA mediated regulation of metabolic pathways involved in colon cancer progression (BST1-microRNA interactions). ESMO Open, 3, A364.

Chosa, N., & Ishisaki, A. (2018). Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell–cell adhesion through N-cadherin. Japanese Dental Science Review, 54(1), 37-44.

Higashida, H., Liang, M., Yoshihara, T., Akther, S., Fakhrul, A., Stanislav, C., ... & Lopatina, O. (2017). An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator. BMC neuroscience, 18(1), 1-12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

BST1 Matched Antibody Pair (144) (CAT#: APMAB-144LY)

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BST1 Matched Antibody Pair (144) (CAT#: APMAB-144LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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