BST1

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]

Bone Marrow Stromal Cell Antigen 1

Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Humoral immune response Source: ParkinsonsUK-UCL
NAD metabolic process Source: Reactome
Neutrophil degranulation Source: Reactome
Positive regulation of B cell proliferation Source: GO_Central
Positive regulation of cell population proliferation Source: ParkinsonsUK-UCL
Regulation of actin cytoskeleton organization Source: ParkinsonsUK-UCL
Regulation of calcium-mediated signaling Source: ParkinsonsUK-UCL
Regulation of cell-matrix adhesion Source: ParkinsonsUK-UCL
Regulation of cellular extravasation Source: ParkinsonsUK-UCL
Regulation of inflammatory response Source: ParkinsonsUK-UCL
Regulation of integrin-mediated signaling pathway Source: ParkinsonsUK-UCL
Regulation of neutrophil chemotaxis Source: ParkinsonsUK-UCL
Regulation of peptidyl-tyrosine phosphorylation Source: ParkinsonsUK-UCL
Regulation of superoxide metabolic process Source: ParkinsonsUK-UCL
Signal transduction Source: ParkinsonsUK-UCL

Cell membrane