Sign in or Register   Sign in or Register
  |  

Rat Anti-BTNL2 Recombinant Antibody (CBYY-0924) (CBMAB-0927-YY)

This product is rabbit antibody that recognizes BTNL2. The antibody CBYY-0924 can be used for immunoassay techniques such as: WB
See all BTNL2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-0924
Antibody Isotype
IgG1
Application
E

Basic Information

Immunogen
Recombinant protein of full length mouse BTNL2.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:1,000-1:4,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 229-259

Target

Full Name
Butyrophilin Like 2
Introduction
This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory Bovinewel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017]
Entrez Gene ID
56244
UniProt ID
Q9UIR0
Alternative Names
Butyrophilin Like 2; Butyrophilin-Like 2 (MHC Class II Associated); BTL-II; Butyrophilin-Like Protein 2; Butyrophilin-Like 2; Truncated BTNL2; HSBLMHC1; BTN7; SS2;
Function
Negative regulator of T-cell proliferation.
Biological Process
Adaptive immune response Source: Reactome
Regulation of cytokine production Source: GO_Central
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Membrane. Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.
Involvement in disease
Sarcoidosis 2 (SS2): Disease susceptibility is associated with variants affecting the gene represented in this entry. A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis. An idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved.
Topology
Cytoplasmic: 1-6 aa
Helical: 7-23 aa
Extracellular: 24-455 aa

Panea, C., Zhang, R., VanValkenburgh, J., Ni, M., Adler, C., Wei, Y., ... & Haxhinasto, S. (2021). Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes. Communications Biology, 4(1), 1-16.

Subair, H. H., Ahmad, A., Djaharuddin, I., Handayani, I., Tenriola, A., Ibrahim, A., ... & Massi, M. N. (2021). Plasma Butyrophilin-Like-2 (Btnl2) Profile Associated with Pulmonary Tuberculosis (Tb) Active and Latent TB Infection. Annals of the Romanian Society for Cell Biology, 25(6), 14043-14048.

Basak, A. J., Maiti, S., Hansda, A., Mahata, D., Duraivelan, K., Kundapura, S. V., ... & Samanta, D. (2020). Structural Insights into N-terminal IgV Domain of BTNL2, a T Cell Inhibitory Molecule, Suggests a Non-canonical Binding Interface for Its Putative Receptors. Journal of Molecular Biology, 432(22), 5938-5950.

Tian, X., Lin, Y., Cui, C., Su, M., & Lai, L. (2019). Type 1 Diabetes: BTNL2‐Ig Protein Attenuates Type 1 Diabetes in Non‐Obese Diabetic (NOD) Mice (Adv. Healthcare Mater. 9/2019). Advanced Healthcare Materials, 8(9), 1970038.

Chaperon, M., Pacheco, Y., Maucort-Boulch, D., Iwaz, J., Perard, L., Broussolle, C., ... & Seve, P. (2019). BTNL2 gene polymorphism and sarcoid uveitis. British Journal of Ophthalmology, 103(12), 1690-1694.

Cui, C., Tian, X., Lin, Y., Su, M., Chen, Q., Wang, S. Y., & Lai, L. (2019). In vivo administration of recombinant BTNL2-Fc fusion protein ameliorates graft-versus-host disease in mice. Cellular immunology, 335, 22-29.

Chaperon, M., Pachéco, Y., Maucort-Boulch, D., Perard, L., Broussolle, C., Jamilloux, Y., ... & Sève, P. (2017). Polymorphisme du gène BTNL2 et uvéite sarcoïdosique. La Revue de Médecine Interne, 38, A83-A84.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-BTNL2 Recombinant Antibody (CBYY-0924)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare