Human BTNL2 ELISA Kit (V2LY-0626-LY5451)

Name: Human BTNL2 ELISA Kit
SKU: V2LY-0626-LY5451
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0095 ng/mL

Detection Range

0.02-3.8 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

50.4 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Butyrophilin Like 2

Function

Negative regulator of T-cell proliferation.

Biological Process

Adaptive immune response Source: Reactome
Regulation of cytokine production Source: GO_Central
T cell receptor signaling pathway Source: GO_Central

Cellular Location

Membrane. Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.

Involvement in disease

Sarcoidosis 2 (SS2): Disease susceptibility is associated with variants affecting the gene represented in this entry. A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis. An idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved.

Topology

Cytoplasmic: 1-6 aa
Helical: 7-23 aa
Extracellular: 24-455 aa

Panea, C., Zhang, R., VanValkenburgh, J., Ni, M., Adler, C., Wei, Y., ... & Haxhinasto, S. (2021). Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes. Communications Biology, 4(1), 1-16.

Subair, H. H., Ahmad, A., Djaharuddin, I., Handayani, I., Tenriola, A., Ibrahim, A., ... & Massi, M. N. (2021). Plasma Butyrophilin-Like-2 (Btnl2) Profile Associated with Pulmonary Tuberculosis (Tb) Active and Latent TB Infection. Annals of the Romanian Society for Cell Biology, 25(6), 14043-14048.

Basak, A. J., Maiti, S., Hansda, A., Mahata, D., Duraivelan, K., Kundapura, S. V., ... & Samanta, D. (2020). Structural Insights into N-terminal IgV Domain of BTNL2, a T Cell Inhibitory Molecule, Suggests a Non-canonical Binding Interface for Its Putative Receptors. Journal of Molecular Biology, 432(22), 5938-5950.

Tian, X., Lin, Y., Cui, C., Su, M., & Lai, L. (2019). Type 1 Diabetes: BTNL2‐Ig Protein Attenuates Type 1 Diabetes in Non‐Obese Diabetic (NOD) Mice (Adv. Healthcare Mater. 9/2019). Advanced Healthcare Materials, 8(9), 1970038.

Chaperon, M., Pacheco, Y., Maucort-Boulch, D., Iwaz, J., Perard, L., Broussolle, C., ... & Seve, P. (2019). BTNL2 gene polymorphism and sarcoid uveitis. British Journal of Ophthalmology, 103(12), 1690-1694.

Cui, C., Tian, X., Lin, Y., Su, M., Chen, Q., Wang, S. Y., & Lai, L. (2019). In vivo administration of recombinant BTNL2-Fc fusion protein ameliorates graft-versus-host disease in mice. Cellular immunology, 335, 22-29.

Chaperon, M., Pachéco, Y., Maucort-Boulch, D., Perard, L., Broussolle, C., Jamilloux, Y., ... & Sève, P. (2017). Polymorphisme du gène BTNL2 et uvéite sarcoïdosique. La Revue de Médecine Interne, 38, A83-A84.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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