Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-CFAP298 Recombinant Antibody (CBXC-2139) (CBMAB-C3439-CQ)


See all CFAP298 antibodies
Online Inquiry
Published Data
CBMAB-C3439-CQ-1
Mouse Anti-CFAP298 Recombinant Antibody (CBXC-2139) (CBMAB-C3439-CQ) in Immunoblot
Representative immunoblot analyses of DNAH7, DNAI2, DNAI1, IQUB, LRRC6, C21ORF59, and ZMYND10 in the testis extracts from Zmynd10+/+ and Zmynd10−/− mice. ...View More
Cho, K. J., Noh, S. H., Han, S. M., Choi, W. I., Kim, H. Y., Yu, S., ... & Gee, H. Y. (2018). ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. PLoS Genetics, 14(3), e1007316.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C3439-CQ-2
Mouse Anti-CFAP298 Recombinant Antibody (CBXC-2139) (CBMAB-C3439-CQ) in IF
Immunofluorescence analysis of DNAI2 (green) or acetylated α-tubulin (Ac-α-tub, green) and C21ORF59 (red) in mTECs. At ALI day 14, C21ORF59 was observed in the cytoplasm whereas DNAI2 was localized in both cytoplasm and cilia in Zmynd10+/+ mTECs. DNAI2 and C21ORF59 were downregulated in Zmynd10-deficient mTECs. Scale bars, 10 μm. ...View More
Cho, K. J., Noh, S. H., Han, S. M., Choi, W. I., Kim, H. Y., Yu, S., ... & Gee, H. Y. (2018). ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. PLoS Genetics, 14(3), e1007316.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Cattle, Pig
Clone
CBXC-2139
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 149-177 within an internal region of CFAP298 of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Cattle, Pig
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cilia And Flagella Associated Protein 298
Introduction
This gene a protein plays a critical role in dynein arm assembly and motile cilia function. Mutations in this gene result in primary ciliary dyskinesia.
Entrez Gene ID
56683
UniProt ID
P57076
Alternative Names
C21orf48; CILD26; FBB18; Kur
Function
Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744).
Seems to be important for initiation rather than maintenance of cilium motility (By similarity).
Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity).
May suppress canonical Wnt signaling activity (By similarity).
Biological Process
Cilium assembly Source: UniProtKB
Regulation of cilium movement Source: UniProtKB
Cellular Location
Cytoplasm; Cilium basal body.Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization.
Involvement in disease
Ciliary dyskinesia, primary, 26 (CILD26): The disease is caused by variants affecting the gene represented in this entry. Cilia in nasal epithelia show the absence of both outer and inner dynein-arm components and complete paralysis. A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CFAP298 Recombinant Antibody (CBXC-2139)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry