Mouse Anti-C4BPA Recombinant Antibody (10-07) (CBMAB-C2011-LY)

Name: Mouse Anti-C4BPA Recombinant Antibody (10-07)
SKU: CBMAB-C2011-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

10-07

Application

Immunogen

Native human C4 binding protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BBS

Preservative

0.09% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

complement component 4 binding protein alpha

Entrez Gene ID

722

UniProt ID

P04003

Function

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

Biological Process

Complement activation, classical pathway Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Negative regulation of complement activation, classical pathway Source: BHF-UCL
Positive regulation of protein catabolic process Source: BHF-UCL
Regulation of complement activation Source: Reactome
Regulation of opsonization Source: BHF-UCL
Response to symbiotic bacterium Source: BHF-UCL

Cellular Location

Secreted

Sasaki, K., Takano, S., Tomizawa, S., Miyahara, Y., Furukawa, K., Takayashiki, T., ... & Ohtsuka, M. (2021). C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer. Journal of Experimental & Clinical Cancer Research, 40(1), 1-16.

Liu, X., Jiang, C., & Yang, P. (2017). Association of single nucleotide polymorphisms in the 5'upstream region of the C4BPA gene with essential hypertension in a northeastern Han Chinese population. Molecular medicine reports, 16(2), 1289-1297.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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