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Mouse Anti-C4BPA Recombinant Antibody (CBFYC-0645) (CBMAB-C0699-FY)

This product is mouse antibody that recognizes C4BPA. The antibody CBFYC-0645 can be used for immunoassay techniques such as: ELISA.
See all C4BPA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0645
Antibody Isotype
IgG2b
Application
ELISA

Basic Information

Immunogen
Native human Complement Component 4 Binding Protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
complement component 4 binding protein alpha
Introduction
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster.
Entrez Gene ID
722
UniProt ID
P04003
Alternative Names
PRP; C4BP
Function
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
Biological Process
Complement activation, classical pathway Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Negative regulation of complement activation, classical pathway Source: BHF-UCL
Positive regulation of protein catabolic process Source: BHF-UCL
Regulation of complement activation Source: Reactome
Regulation of opsonization Source: BHF-UCL
Response to symbiotic bacterium Source: BHF-UCL
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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