Mouse Anti-C4BPA Recombinant Antibody (CBFYC-0645) (CBMAB-C0699-FY)

Name: Mouse Anti-C4BPA Recombinant Antibody (CBFYC-0645)
SKU: CBMAB-C0699-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-0645

Application

WB, IP, IF, E

Immunogen

Amino acids 294-491 mapping near the C-terminus of C4BPα of human origin.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

complement component 4 binding protein alpha

Introduction

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster.

Entrez Gene ID

722

UniProt ID

P04003

Alternative Names

PRP; C4BP

Function

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

Biological Process

Complement activation, classical pathway Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Negative regulation of complement activation, classical pathway Source: BHF-UCL
Positive regulation of protein catabolic process Source: BHF-UCL
Regulation of complement activation Source: Reactome
Regulation of opsonization Source: BHF-UCL
Response to symbiotic bacterium Source: BHF-UCL

Cellular Location

Secreted

Sasaki, K., Takano, S., Tomizawa, S., Miyahara, Y., Furukawa, K., Takayashiki, T., ... & Ohtsuka, M. (2021). C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer. Journal of Experimental & Clinical Cancer Research, 40(1), 1-16.

Liu, X., Jiang, C., & Yang, P. (2017). Association of single nucleotide polymorphisms in the 5'upstream region of the C4BPA gene with essential hypertension in a northeastern Han Chinese population. Molecular medicine reports, 16(2), 1289-1297.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-C4BPA Recombinant Antibody (10-07) (CAT#: CBMAB-C2011-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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