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Rabbit Anti-C9orf72 Recombinant Antibody (13H20L17) (CBMAB-1254-CN)

This product is a rabbit antibody that recognizes C9orf72 of human. The antibody 13H20L17 can be used for immunoassay techniques such as: WB.
See all C9orf72 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Pig, Sheep, Cattle
Clone
13H20L17
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Protein corresponding to human C9ORF72 (aa. 1-200)
Specificity
Human, Mouse, Rat, Monkey, Pig, Sheep, Cattle
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C9orf72-SMCR8 Complex Subunit
Introduction
The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia). The protein may be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation.
Entrez Gene ID
Human203228
Mouse73205
Rat103730681
Monkey706828
Pig100515791
Sheep101111774
Cattle109562824
UniProt ID
HumanQ96LT7
MouseQ6DFW0
RatQ66HC3
MonkeyH2QX41
PigA0A287AZU9
SheepW5PZ61
CattleA6QR41
Alternative Names
ALSFTD; FTDALS; DENNL72; FTDALS1
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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