Rabbit Anti-C9orf72 Recombinant Antibody (RB) (CBMAB-1254-CN)

Name: Rabbit Anti-C9orf72 Recombinant Antibody (RB)
SKU: CBMAB-1254-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

Application

WB, IF, P

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human C9orf72.

Host Species

Rabbit

Specificity

Human, Mouse, Rat, Monkey, Pig, Sheep, Cattle

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

C9orf72-SMCR8 Complex Subunit

Introduction

The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia). The protein may be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation.

Entrez Gene ID

Human	203228
Mouse	73205
Rat	103730681
Monkey	706828
Pig	100515791
Sheep	101111774
Cattle	109562824

UniProt ID

Human	Q96LT7
Mouse	Q6DFW0
Rat	Q66HC3
Monkey	H2QX41
Pig	A0A287AZU9
Sheep	W5PZ61
Cattle	A6QR41

Alternative Names

ALSFTD; FTDALS; DENNL72; FTDALS1

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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