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Rabbit Anti-CAB39 Recombinant Antibody (CBLC275-LY) (CBMAB-C9598-LY)

The product is antibody recognizes CAB39. The antibody CBLC275-LY immunoassay techniques such as: WB, IHC, ICC, FC.
See all CAB39 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBLC275-LY
Antibody Isotype
IgG
Application
WB, IHC, ICC, FC

Basic Information

Immunogen
A synthetic peptide corresponding to residues on the C-terminus of human Mo25 was used as an immunogen
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol , 0.05% BSA
Preservative
0.01% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calcium Binding Protein 39
Introduction
CAB39 (Calcium Binding Protein 39) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling. Gene Ontology (GO) annotations related to this gene include binding and kinase binding. An important paralog of this gene is CAB39L.
Entrez Gene ID
Human51719
Rat301574
Mouse12283
UniProt ID
HumanQ9Y376
RatD3ZJ77
MouseQ06138
Alternative Names
Calcium Binding Protein 39; MO25alpha; MO25; Calcium-Binding Protein 39; Protein Mo25; CGI-66;
Function
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Biological Process
Cell cycle arrest Source: Reactome
Cellular hypotonic response Source: ParkinsonsUK-UCL
Intracellular signal transduction Source: ParkinsonsUK-UCL
Negative regulation of potassium ion transmembrane transport Source: ParkinsonsUK-UCL
Negative regulation of potassium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
Neutrophil degranulation Source: Reactome
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of protein serine/threonine kinase activity Source: ParkinsonsUK-UCL
Response to activity Source: Ensembl
Response to thyroid hormone Source: Ensembl
Signal transduction Source: ParkinsonsUK-UCL
Cellular Location
Cytoplasm

Zhang, S., Zhang, R., Qiao, P., Ma, X., Lu, R., Wang, F., ... & Liu, H. (2021). Metformin-induced MicroRNA-34a-3p downregulation alleviates senescence in human dental pulp stem cells by targeting CAB39 through the AMPK/mTOR signaling pathway. Stem Cells International, 2021.

Chao, H., Peng, L., Deng, L., Yu, Z., Deng, H., Xu, F., ... & Zeng, T. (2021). CAB39 mediates epithelial-mesenchymal transition via activation of NF-κB signaling to facilitate bladder cancer invasion and metastasis.

Liang, Y., Zhu, D., Hou, L., Wang, Y., Huang, X., Zhou, C., ... & Meng, X. (2020). MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39. British journal of cancer, 122(5), 705-714.

Zhuang, Y., Wang, S., Fei, H., Ji, F., & Sun, P. (2020). miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity. Aging (Albany NY), 12(12), 11754.

Jiang, W. L., Zhao, K. C., Yuan, W., Zhou, F., Song, H. Y., Liu, G. L., ... & Xie, S. P. (2020). MicroRNA-31-5p exacerbates lipopolysaccharide-induced acute lung injury via inactivating Cab39/AMPKα pathway. Oxidative medicine and cellular longevity, 2020.

Li, K., Cao, J., Zhang, Z., Chen, K., Ma, T., Yang, W., ... & Zhang, K. (2020). Circular RNA circGSK3B Promotes Cell Proliferation, Migration, and Invasion by Sponging miR-1265 and Regulating CAB39 Expression in Hepatocellular Carcinoma. Frontiers in oncology, 10, 2465.

Peng, L., Yan, H., Qi, S., & Deng, L. (2020). CAB39 Promotes the Proliferation of Nasopharyngeal Carcinoma CNE-1 Cells via Up-Regulating p-JNK. Cancer Management and Research, 12, 11203.

Xu, Z., Li, Z., Wang, W., Xia, Y., He, Z., Li, B., ... & Xu, Z. (2019). MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy. Cancer letters, 449, 226-236.

Yang, F., Liu, S., Sun, J., & Wang, G. (2018). microRNA-22 Promotes the Osteogenic Differentiation of Valvular Interstitial Cells by Targeting Calcium Binding Protein 39. Circulation, 138(Suppl_1), A11504-A11504.

Jiang, L., Yan, Q., Fang, S., Liu, M., Li, Y., Yuan, Y. F., ... & Guan, X. Y. (2017). Calcium‐binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal‐regulated kinase signaling pathway. Hepatology, 66(5), 1529-1545.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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