Human Recombinant CAB39 protein, GST Tag (V2LY-0526-LY2465)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant CAB39 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 63 kDa.
Molecule Mass
63 kDa
Sequence
Amino Acid: Full Length
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
Tris, NaCl, Glutathione, EDTA, DTT, Glycerol
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
Calcium Binding Protein 39
Function
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Biological Process
Cell cycle arrest Source: Reactome
Cellular hypotonic response Source: ParkinsonsUK-UCL
Intracellular signal transduction Source: ParkinsonsUK-UCL
Negative regulation of potassium ion transmembrane transport Source: ParkinsonsUK-UCL
Negative regulation of potassium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
Neutrophil degranulation Source: Reactome
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of protein serine/threonine kinase activity Source: ParkinsonsUK-UCL
Response to activity Source: Ensembl
Response to thyroid hormone Source: Ensembl
Signal transduction Source: ParkinsonsUK-UCL
Cellular Location
Cytoplasm

Zhang, S., Zhang, R., Qiao, P., Ma, X., Lu, R., Wang, F., ... & Liu, H. (2021). Metformin-induced MicroRNA-34a-3p downregulation alleviates senescence in human dental pulp stem cells by targeting CAB39 through the AMPK/mTOR signaling pathway. Stem Cells International, 2021.

Chao, H., Peng, L., Deng, L., Yu, Z., Deng, H., Xu, F., ... & Zeng, T. (2021). CAB39 mediates epithelial-mesenchymal transition via activation of NF-κB signaling to facilitate bladder cancer invasion and metastasis.

Liang, Y., Zhu, D., Hou, L., Wang, Y., Huang, X., Zhou, C., ... & Meng, X. (2020). MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39. British journal of cancer, 122(5), 705-714.

Zhuang, Y., Wang, S., Fei, H., Ji, F., & Sun, P. (2020). miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity. Aging (Albany NY), 12(12), 11754.

Jiang, W. L., Zhao, K. C., Yuan, W., Zhou, F., Song, H. Y., Liu, G. L., ... & Xie, S. P. (2020). MicroRNA-31-5p exacerbates lipopolysaccharide-induced acute lung injury via inactivating Cab39/AMPKα pathway. Oxidative medicine and cellular longevity, 2020.

Li, K., Cao, J., Zhang, Z., Chen, K., Ma, T., Yang, W., ... & Zhang, K. (2020). Circular RNA circGSK3B Promotes Cell Proliferation, Migration, and Invasion by Sponging miR-1265 and Regulating CAB39 Expression in Hepatocellular Carcinoma. Frontiers in oncology, 10, 2465.

Peng, L., Yan, H., Qi, S., & Deng, L. (2020). CAB39 Promotes the Proliferation of Nasopharyngeal Carcinoma CNE-1 Cells via Up-Regulating p-JNK. Cancer Management and Research, 12, 11203.

Xu, Z., Li, Z., Wang, W., Xia, Y., He, Z., Li, B., ... & Xu, Z. (2019). MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy. Cancer letters, 449, 226-236.

Yang, F., Liu, S., Sun, J., & Wang, G. (2018). microRNA-22 Promotes the Osteogenic Differentiation of Valvular Interstitial Cells by Targeting Calcium Binding Protein 39. Circulation, 138(Suppl_1), A11504-A11504.

Jiang, L., Yan, Q., Fang, S., Liu, M., Li, Y., Yuan, Y. F., ... & Guan, X. Y. (2017). Calcium‐binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal‐regulated kinase signaling pathway. Hepatology, 66(5), 1529-1545.

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For research use only. Not intended for any clinical use.

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