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Mouse Anti-CABP1 Recombinant Antibody (F5) (CBMAB-1257-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
F5
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, E

Basic Information

Immunogen
Amino acids 317-353 mapping within an internal region of CaBP1 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
calcium binding protein 1
Introduction
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. It also prevents NMDA receptor-induced cellular degeneration.
Entrez Gene ID
Human9478
Mouse29867
UniProt ID
HumanQ9NZU7
MouseQ9JLK7
Alternative Names
CALBRAIN; HCALB_BR
Function
Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872).
Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432).
Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310).
Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941).
Suppresses the calcium-dependent inactivation of CACNA1D (By similarity).
Inhibits TRPC5 channels (PubMed:15895247).
Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).
Biological Process
Negative regulation of protein import into nucleus Source: UniProtKB
Response to stimulus Source: UniProtKB-KW
Visual perception Source: UniProtKB
Cellular Location
Golgi apparatus; Cytoskeleton; Cell membrane; Perinuclear region; Postsynaptic density. L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.
Isoform L-CaBP1: Cytoskeleton. L-CaBP1 is associated most likely with the cytoskeletal structures.
Isoform S-CaBP1: Cell membrane; Cell cortex. S-CaBP1 is localized at or near the plasma membrane.
PTM
Phosphorylated. The phosphorylation regulates the activity.
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For research use only. Not intended for any clinical use.

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