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Rabbit Anti-CABP1 Recombinant Antibody (EPR7916) (CBMAB-1257-CN)

This product is a rabbit antibody that recognizes CABP1 of human. The antibody EPR7916 can be used for immunoassay techniques such as: WB.
See all CABP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EPR7916
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
A synthetic peptide corresponding to residues in Human CABP.
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
calcium binding protein 1
Introduction
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. It also prevents NMDA receptor-induced cellular degeneration.
Entrez Gene ID
Human9478
Mouse29867
UniProt ID
HumanQ9NZU7
MouseQ9JLK7
Alternative Names
CALBRAIN; HCALB_BR
Function
Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872).
Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432).
Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310).
Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941).
Suppresses the calcium-dependent inactivation of CACNA1D (By similarity).
Inhibits TRPC5 channels (PubMed:15895247).
Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).
Biological Process
Negative regulation of protein import into nucleus Source: UniProtKB
Response to stimulus Source: UniProtKB-KW
Visual perception Source: UniProtKB
Cellular Location
Golgi apparatus; Cytoskeleton; Cell membrane; Perinuclear region; Postsynaptic density. L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.
Isoform L-CaBP1: Cytoskeleton. L-CaBP1 is associated most likely with the cytoskeletal structures.
Isoform S-CaBP1: Cell membrane; Cell cortex. S-CaBP1 is localized at or near the plasma membrane.
PTM
Phosphorylated. The phosphorylation regulates the activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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