Mouse Anti-CABP4 Recombinant Antibody (CBXC-0035) (CBMAB-C5189-CQ)

Name: Mouse Anti-CABP4 Recombinant Antibody (CBXC-0035)
SKU: CBMAB-C5189-CQ
Rating: 5 (1 reviews)

See all CABP4 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-0035

Application

Immunogen

Full length human recombinant protein of human CABP4 produced in E.coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

calcium binding protein 4

Introduction

This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene.

Entrez Gene ID

57010

UniProt ID

P57796

Alternative Names

Calcium Binding Protein 4; Calcium-Binding Protein 4; CSNB2B; CaBP4; CRSD;

Function

Involved in normal synaptic function through regulation of Ca2+ influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).

Biological Process

Photoreceptor cell morphogenesis Source: Ensembl
Phototransduction Source: Ensembl
Retinal bipolar neuron differentiation Source: Ensembl
Retinal cone cell development Source: Ensembl
Signal transduction Source: UniProtKB
Visual perception Source: UniProtKB

Cellular Location

Cytoplasm; Presynapse. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.

Involvement in disease

Cone-rod synaptic disorder, congenital non-progressive (CRSD): A non-progressive retinal disorder characterized by stable low vision, nystagmus, photophobia, a normal or near-normal fundus appearance, and no night blindness.

PTM

Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity (By similarity).

Ehsan, M., Hu, R. S., Hou, J. L., Elsheikha, H. M., Li, X. D., Liang, P. H., & Zhu, X. Q. (2021). Fasciola gigantica tegumental calcium-binding EF-hand protein 4 exerts immunomodulatory effects on goat monocytes. Parasites & vectors, 14(1), 1-15.

Smirnov, V. M., Zeitz, C., Soumittra, N., Audo, I., & Defoort-Dhellemmes, S. (2018). Retinal findings in a patient of French ancestry with CABP4-related retinal disease. Documenta Ophthalmologica, 136(2), 135-143.

Chen, Z. H., Wang, C., Zhuo, M. Q., Zhai, Q. X., Chen, Q., Guo, Y. X., ... & Zeng, X. L. (2017). Exome sequencing identified a novel missense mutation c. 464G> A (p. G155D) in Ca2+-binding protein 4 (CABP4) in a Chinese pedigree with autosomal dominant nocturnal frontal lobe epilepsy. Oncotarget, 8(45), 78940.

Schatz, P., Abdalla Elsayed, M. E., & Khan, A. O. (2017). Multimodal imaging in CABP4-related retinopathy. Ophthalmic genetics, 38(5), 459-464.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-CABP4 Recombinant Antibody (CBXC-0035)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CABP4 Recombinant Antibody (5G11) (CAT#: CBMAB-C7657-LY)

Mouse Anti-CABP4 Recombinant Antibody (CBXC-3116) (CAT#: CBMAB-C5188-CQ)

Mouse Anti-CABP4 Recombinant Antibody (CBXC-1800) (CAT#: CBMAB-C3605-CQ)

Mouse Anti-CABP4 Recombinant Antibody (CBYY-C0856) (CAT#: CBMAB-C2292-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry