CABP4

This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Full Name
calcium binding protein 4
Function
Involved in normal synaptic function through regulation of Ca2+ influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).
Biological Process
Photoreceptor cell morphogenesis Source: Ensembl
Phototransduction Source: Ensembl
Retinal bipolar neuron differentiation Source: Ensembl
Retinal cone cell development Source: Ensembl
Signal transduction Source: UniProtKB
Visual perception Source: UniProtKB
Cellular Location
Cytoplasm; Presynapse. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.
Involvement in disease
Cone-rod synaptic disorder, congenital non-progressive (CRSD): A non-progressive retinal disorder characterized by stable low vision, nystagmus, photophobia, a normal or near-normal fundus appearance, and no night blindness.
PTM
Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity (By similarity).
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Anti-CABP4 antibodies

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Mouse Anti-CABP4 Recombinant Antibody (CBYY-C0856) (CBMAB-C2292-YY)

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Target: CABP4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C0856
Application*: E, WB
Datasheet SDS

Mouse Anti-CABP4 Recombinant Antibody (5G11) (CBMAB-C7657-LY)

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Target: CABP4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5G11
Application*: E, WB
Datasheet SDS

Mouse Anti-CABP4 Recombinant Antibody (CBXC-0035) (CBMAB-C5189-CQ)

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Target: CABP4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-0035
Application*: WB
Datasheet SDS

Mouse Anti-CABP4 Recombinant Antibody (CBXC-3116) (CBMAB-C5188-CQ)

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Target: CABP4
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Mouse
Clone: CBXC-3116
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CABP4 Recombinant Antibody (CBXC-1800) (CBMAB-C3605-CQ)

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Target: CABP4
Host: Mouse
Antibody Isotype: IgA, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-1800
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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