CABP4

This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Full Name

calcium binding protein 4

Function

Involved in normal synaptic function through regulation of Ca2+ influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).

Biological Process

Photoreceptor cell morphogenesis Source: Ensembl
Phototransduction Source: Ensembl
Retinal bipolar neuron differentiation Source: Ensembl
Retinal cone cell development Source: Ensembl
Signal transduction Source: UniProtKB
Visual perception Source: UniProtKB

Cellular Location

Cytoplasm; Presynapse. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.

Involvement in disease

Cone-rod synaptic disorder, congenital non-progressive (CRSD): A non-progressive retinal disorder characterized by stable low vision, nystagmus, photophobia, a normal or near-normal fundus appearance, and no night blindness.

PTM

Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity (By similarity).

Anti-CABP4 antibodies

Mouse Anti-CABP4 Recombinant Antibody (5G11) (CBMAB-C7657-LY)

Datasheet

SDS

Target: CABP4

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 5G11

Application*: E, WB

Mouse Anti-CABP4 Recombinant Antibody (CBYY-C0856) (CBMAB-C2292-YY)

Datasheet

SDS

Target: CABP4

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYY-C0856

Application*: E, WB

Mouse Anti-CABP4 Recombinant Antibody (CBXC-1800) (CBMAB-C3605-CQ)

Datasheet

SDS

Target: CABP4

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXC-1800

Application*: WB, IP, IF, E

Mouse Anti-CABP4 Recombinant Antibody (CBXC-3116) (CBMAB-C5188-CQ)

Datasheet

SDS

Target: CABP4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-3116

Application*: WB

Mouse Anti-CABP4 Recombinant Antibody (CBXC-0035) (CBMAB-C5189-CQ)

Datasheet

SDS

Target: CABP4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXC-0035

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)