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CABP4

This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Full Name

calcium binding protein 4

Function

Involved in normal synaptic function through regulation of Ca2+ influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).

Biological Process

Photoreceptor cell morphogenesis Source: Ensembl
Phototransduction Source: Ensembl
Retinal bipolar neuron differentiation Source: Ensembl
Retinal cone cell development Source: Ensembl
Signal transduction Source: UniProtKB
Visual perception Source: UniProtKB

Cellular Location

Cytoplasm; Presynapse. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.

Involvement in disease

Cone-rod synaptic disorder, congenital non-progressive (CRSD): A non-progressive retinal disorder characterized by stable low vision, nystagmus, photophobia, a normal or near-normal fundus appearance, and no night blindness.

PTM

Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity (By similarity).

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Anti-CABP4 antibodies

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Mouse Anti-CABP4 Recombinant Antibody (CBYY-C0856) (CBMAB-C2292-YY)

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Target: CABP4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYY-C0856

Application*: E, WB

Mouse Anti-CABP4 Recombinant Antibody (5G11) (CBMAB-C7657-LY)

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Target: CABP4

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 5G11

Application*: E, WB

Mouse Anti-CABP4 Recombinant Antibody (CBXC-0035) (CBMAB-C5189-CQ)

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Target: CABP4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-0035

Application*: WB

Mouse Anti-CABP4 Recombinant Antibody (CBXC-3116) (CBMAB-C5188-CQ)

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Target: CABP4

Host: Mouse

Antibody Isotype: IgG1, λ

Specificity: Mouse

Clone: CBXC-3116

Application*: WB, IP, IF, E

Mouse Anti-CABP4 Recombinant Antibody (CBXC-1800) (CBMAB-C3605-CQ)

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Target: CABP4

Host: Mouse

Antibody Isotype: IgA, κ

Specificity: Human, Mouse, Rat

Clone: CBXC-1800

Application*: WB, IP, IF, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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