Mouse Anti-CACNB2 Recombinant Antibody (5C10) (CBMAB-C2328-LY)

Name: Mouse Anti-CACNB2 Recombinant Antibody (5C10)
SKU: CBMAB-C2328-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

5C10

Application

E, WB

Immunogen

CACNB2 (NP_963890, 213 a.a. ~ 301 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2

Entrez Gene ID

Human	783
Mouse	12296
Rat	116600

UniProt ID

Human	Q08289
Mouse	Q8CC27
Rat	Q8VGC3

Function

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Biological Process

Calcium ion import Source: BHF-UCL
Cardiac conduction Source: Reactome
Chemical synaptic transmission Source: GO_Central
Membrane depolarization during atrial cardiac muscle cell action potential Source: BHF-UCL
Membrane depolarization during AV node cell action potential Source: BHF-UCL
Neuromuscular junction development Source: GO_Central
Positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL
Positive regulation of calcium ion transport Source: BHF-UCL
Positive regulation of high voltage-gated calcium channel activity Source: BHF-UCL
Protein localization to plasma membrane Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of voltage-gated calcium channel activity Source: GO_Central
Visual perception Source: Ensembl

Cellular Location

Sarcolemma

Involvement in disease

Brugada syndrome 4 (BRGDA4): A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.

PTM

Regulated through phosphorylation at Thr-554 by CaMK2D.

Graziano, C., Despang, P., Palombo, F., Severi, G., Posar, A., Cassio, A., ... & Bonora, E. (2021). A new homozygous CACNB2 mutation has functional relevance and supports a role for calcium channels in autism spectrum disorder. Journal of Autism and Developmental Disorders, 51, 377-381.

Martins, H. C., Sungur, O. A., Gilardi, C., Pelzl, M., Bicker, S., Gross, F., ... & Schratt, G. (2021). Bipolar-associated miR-499-5p controls neuroplasticity by downregulating the Cav1. 2 L-type voltage gated calcium channel subunit CACNB2. bioRxiv.

Oyamada, J., Shimizu, C., Kim, J., Williams, M. R., Png, E., Hibberd, M. L., ... & Burns, J. C. (2019). Bifid T waves on the ECG and genetic variation in calcium channel voltage‐dependent beta 2 subunit gene (CACNB2) in acute Kawasaki disease. Congenital heart disease, 14(2), 213-220.

Pandian, V. D., Giovannucci, D. R., Vazquez, G., & Kumarasamy, S. (2019). CACNB2 is associated with aberrant RAS-MAPK signaling in hypertensive Dahl salt-sensitive rats. Biochemical and biophysical research communications, 513(3), 760-765.

Liu, F., Gong, X., Yao, X., Cui, L., Yin, Z., Li, C., ... & Wang, F. (2019). Variation in the CACNB2 gene is associated with functional connectivity of the Hippocampus in bipolar disorder. BMC psychiatry, 19(1), 1-7.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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