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Mouse Anti-CACNB2 Recombinant Antibody (5B6) (CBMAB-C8110-LY)

This product is antibody recognizes CACNB2. The antibody 6C1 immunoassay techniques such as: ELISA, WB.
See all CACNB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
5B6
Antibody Isotype
IgG2a, κ
Application
E, WB

Basic Information

Immunogen
CACNB2 (NP_963890, 213 a.a. ~ 301 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2
Entrez Gene ID
Human783
Mouse12296
Rat116600
UniProt ID
HumanQ08289
MouseQ8CC27
RatQ8VGC3
Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Biological Process
Calcium ion import Source: BHF-UCL
Cardiac conduction Source: Reactome
Chemical synaptic transmission Source: GO_Central
Membrane depolarization during atrial cardiac muscle cell action potential Source: BHF-UCL
Membrane depolarization during AV node cell action potential Source: BHF-UCL
Neuromuscular junction development Source: GO_Central
Positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL
Positive regulation of calcium ion transport Source: BHF-UCL
Positive regulation of high voltage-gated calcium channel activity Source: BHF-UCL
Protein localization to plasma membrane Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of voltage-gated calcium channel activity Source: GO_Central
Visual perception Source: Ensembl
Cellular Location
Sarcolemma
Involvement in disease
Brugada syndrome 4 (BRGDA4): A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.
PTM
Regulated through phosphorylation at Thr-554 by CaMK2D.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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