Mouse Anti-CACNG2 Recombinant Antibody (CBXS-5376) (CBMAB-S2589-CQ)

Name: Mouse Anti-CACNG2 Recombinant Antibody (CBXS-5376)
SKU: CBMAB-S2589-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-5376

Application

WB, IP, IF, E

Immunogen

Amino acids 263-291 within an internal region of L-type Ca++ CP γ2 of mouse origin.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Horse, Cattle, Dog, Pig

Antibody Isotype

IgG2b, λ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

calcium voltage-gated channel auxiliary subunit gamma 2

Introduction

CACNG2 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2) is a Protein Coding gene. Diseases associated with CACNG2 include Mental Retardation, Autosomal Dominant 10 and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are Cardiac conduction and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity and ionotropic glutamate receptor binding. An important paralog of this gene is CACNG3.

Entrez Gene ID

Human	10369
Mouse	12300
Rat	84347

UniProt ID

Human	Q9Y698
Mouse	O88602
Rat	Q71RJ2

Alternative Names

Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2; Neuronal Voltage-Gated Calcium Channel Gamma-2 Subunit; Transmembrane AMPAR Regulatory Protein Gamma-2; TARP Gamma-2; Calcium Channel, Voltage-Dependent, Gamma Subunit 2; Voltage-Dependent Calcium Channel Gamma-2 Subunit; Stargazin; MRD10;

Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

Biological Process

Eye blink reflex Source: Ensembl
Membrane depolarization Source: Reactome
Membrane hyperpolarization Source: Ensembl
Neuromuscular junction development Source: Ensembl
Neurotransmitter receptor internalization Source: GO_Central
Neurotransmitter receptor transport, postsynaptic endosome to lysosome Source: GO_Central
Positive regulation of AMPA receptor activity Source: Ensembl
Positive regulation of protein localization to basolateral plasma membrane Source: Ensembl
Positive regulation of synaptic transmission, glutamatergic Source: GO_Central
Postsynaptic neurotransmitter receptor diffusion trapping Source: GO_Central
Protein targeting to membrane Source: Ensembl
Regulation of AMPA receptor activity Source: UniProtKB
Response to calcium ion Source: Ensembl
Transmission of nerve impulse Source: GO_Central

Cellular Location

Membrane; Synaptosome

Involvement in disease

Mental retardation, autosomal dominant 10 (MRD10): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

PTM

Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.

Miranda, A., Shekhtman, T., McCarthy, M., DeModena, A., Leckband, S. G., & Kelsoe, J. R. (2019). Study of 45 candidate genes suggests CACNG2 may be associated with lithium response in bipolar disorder. Journal of affective disorders, 248, 175-179.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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