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Mouse Anti-Cacng2 Recombinant Antibody (D7) (CBMAB-T0063-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Horse, Cattle, Dog
Clone
D7
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, E

Basic Information

Immunogen
Amino acids 244-323 mapping at the C-terminus of L-type Ca++ CP γ2 of human origin.
Host Species
Mouse
Specificity
Human, Horse, Cattle, Dog
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 203-323

Target

Full Name
calcium voltage-gated channel auxiliary subunit gamma 2
Introduction
Cacng2 regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). It promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. It does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. It is thought to stabilize the calcium channel in an inactivated (closed) state.
Entrez Gene ID
Mouse12300
Rat84347
UniProt ID
MouseO88602
RatQ71RJ2
Alternative Names
Ipr328
Function
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Biological Process
Eye blink reflex Source: Ensembl
Membrane depolarization Source: Reactome
Membrane hyperpolarization Source: Ensembl
Neuromuscular junction development Source: Ensembl
Neurotransmitter receptor internalization Source: GO_Central
Neurotransmitter receptor transport, postsynaptic endosome to lysosome Source: GO_Central
Positive regulation of AMPA receptor activity Source: Ensembl
Positive regulation of protein localization to basolateral plasma membrane Source: Ensembl
Positive regulation of synaptic transmission, glutamatergic Source: GO_Central
Postsynaptic neurotransmitter receptor diffusion trapping Source: GO_Central
Protein targeting to membrane Source: Ensembl
Regulation of AMPA receptor activity Source: UniProtKB
Response to calcium ion Source: Ensembl
Transmission of nerve impulse Source: GO_Central
Cellular Location
Membrane; Synaptosome
Involvement in disease
Mental retardation, autosomal dominant 10 (MRD10): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
PTM
Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.
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For research use only. Not intended for any clinical use.

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