Mouse Anti-CALB1 Recombinant Antibody (GT386) (CBMAB-1268-CN)

Name: Mouse Anti-CALB1 Recombinant Antibody (GT386)
SKU: CBMAB-1268-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

GT386

Application

IH, WB

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human Calbindin.

Host Species

Mouse

Specificity

Mouse, Rat

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 20% Glycerol

Preservative

None

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Calbindin 1

Introduction

The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. The protein may stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Entrez Gene ID

793

UniProt ID

P05937

Alternative Names

CALB; D-28K

Function

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Biological Process

Amyloid fibril formation Source: Reactome
Cellular response to organic substance Source: Ensembl
Cochlea development Source: Ensembl
Locomotory behavior Source: Ensembl
Long-term memory Source: UniProtKB
Metanephric collecting duct development Source: Ensembl
Metanephric connecting tubule development Source: Ensembl
Metanephric distal convoluted tubule development Source: Ensembl
Metanephric part of ureteric bud development Source: Ensembl
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of long-term synaptic potentiation Source: GO_Central
Regulation of presynaptic cytosolic calcium ion concentration Source: GO_Central
Retina layer formation Source: Ensembl
Short-term memory Source: UniProtKB

Cellular Location

Cuticular plate; Cytosol; Postsynaptic cytosol; Presynaptic cytosol; Extracellular exosome; Nucleus; Axon; Calyx of Held; Dendrite; Dendritic spine; GABA-ergic synapse; Glutamatergic synapse; Hippocampal mossy fiber to CA3 synapse; Neuron projection; Neuronal cell body; Stereocilium; Synapse; Terminal bouton

Castrogiovanni, P., Sanfilippo, C., Imbesi, R., Maugeri, G., Lo Furno, D., Tibullo, D., ... & Di Rosa, M. (2021). Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients. Cells, 10(4), 882.

of Wang, N., Lavasseur, C. M., Yan, H., Younger, S., Glader, B., Sakamoto, K. M., ... & Narla, A. (2020). Targeting of Calbindin 1 (CALB1) Rescues Erythropoiesis in a Human Model of Diamond Blackfan Anemia: Implications for Novel Therapies. Blood, 136, 4.

Jin, C., Lin, T., & Shan, L. (2019). Downregulation of calbindin 1 by miR-454-3p suppresses cell proliferation in nonsmall cell lung cancer in vitro. Cancer biotherapy & radiopharmaceuticals, 34(2), 119-127.

Cao, L. Q., Wang, Y. N., Liang, M., & Pan, M. Z. (2019). CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells. Molecular medicine reports, 19(6), 5097-5104.

Goffigan-Holmes, J., Sanabria, D., Diaz, J., Flock, D., & Chavez-Valdez, R. (2018). Calbindin-1 expression in the hippocampus following neonatal hypoxia-ischemia and therapeutic hypothermia and deficits in spatial memory. Developmental neuroscience, 40(5-6), 508-522.

Huang, Z., Fan, G., & Wang, D. (2017). Downregulation of calbindin 1, a calcium-binding protein, reduces the proliferation of osteosarcoma cells. Oncology letters, 13(5), 3727-3733.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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