Mouse Anti-CALM2 Recombinant Antibody (J4D8) (CBMAB-C1433-LY)

calmodulin 2 (phosphorylase kinase, delta)

CALM2 (Calmodulin 2) is a Protein Coding gene. Diseases associated with CALM2 include Long Qt Syndrome 15 and Long Qt Syndrome 1. Among its related pathways are RET signaling and N-cadherin signaling events. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is CALM3.

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425).
Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752).
Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).

Detection of calcium ion Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: UniProtKB
Positive regulation of cyclic-nucleotide phosphodiesterase activity Source: BHF-UCL
Positive regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
Positive regulation of phosphoprotein phosphatase activity Source: BHF-UCL
Positive regulation of protein autophosphorylation Source: BHF-UCL
Positive regulation of protein dephosphorylation Source: BHF-UCL
Positive regulation of protein serine/threonine kinase activity Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Regulation of cardiac muscle contraction Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Regulation of cytokinesis Source: UniProtKB
Regulation of heart rate Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Regulation of ryanodine-sensitive calcium-release channel activity Source: GO_Central
Response to calcium ion Source: BHF-UCL
Substantia nigra development Source: UniProtKB

Spindle; Spindle pole; Centrosome. Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.

Long QT syndrome 15 (LQT15): A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

Ubiquitination results in a strongly decreased activity.
Phosphorylation results in a decreased activity.