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Mouse Anti-CALU Recombinant Antibody (CBCNC-141) (CBMAB-C1260-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBCNC-141
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant human CALU(C-terminus) protein fragments expressed in E.coli.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.5% BSA, 50% glycerol
Preservative
0.2% sodium azide
Concentration
Batch dependent

Target

Full Name
Calumenin
Introduction
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Entrez Gene ID
813
UniProt ID
O43852
Alternative Names
Calumenin; IEF SSP 9302; Multiple EF-Hand Protein; Crocalbin-Like Protein; Crocalbin;
Function
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).
Biological Process
Cellular protein metabolic process Source: Reactome
Post-translational protein modification Source: Reactome
Cellular Location
Golgi apparatus; Secreted; Endoplasmic reticulum membrane; Melanosome; Sarcoplasmic reticulum lumen. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
More Infomation

Du, Y., Miao, W., Jiang, X., Cao, J., Wang, B., Wang, Y., ... & Liu, H. (2021). The Epithelial to Mesenchymal Transition Related Gene Calumenin Is an Adverse Prognostic Factor of Bladder Cancer Correlated With Tumor Microenvironment Remodeling, Gene Mutation, and Ferroptosis. Frontiers in Oncology, 11, 1771.

Yang, Y., Wang, J., Xu, S., Shi, F., & Shan, A. (2021). Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma. Translational Neuroscience, 12(1), 67-75.

Nasri Nasrabadi, P., Nayeri, Z., Gharib, E., Salmanipour, R., Masoomi, F., Mahjoubi, F., & Zomorodipour, A. (2020). Establishment of a CALU, AURKA, and MCM2 gene panel for discrimination of metastasis from primary colon and lung cancers. Plos one, 15(5), e0233717.

Philippe, R., & Mignen, O. (2019). Measuring calumenin impact on ER-calcium depletion using transient calumenin overexpression and silencing. In Calcium-Binding proteins of the EF-hand superfamily (pp. 539-550). Humana Press, New York, NY.

Narayanasamy, S., & Aradhyam, G. K. (2018). The Differential Response to Ca2+ from Vertebrate and Invertebrate Calumenin Is Governed by a Single Amino Acid Residue. Biochemistry, 57(5), 722-731.

Wang, Y., Sun, Y., Guo, X., Fu, Y., Long, J., Wei, C. X., & Zhao, M. (2018). Creatine phosphate disodium salt protects against dox-induced cardiotoxicity by increasing calumenin. Medical molecular morphology, 51(2), 96-101.

Philippe, R., Antigny, F., Buscaglia, P., Norez, C., Huguet, F., Castelbou, C., ... & Mignen, O. (2017). Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention. Cell calcium, 62, 47-59.

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For research use only. Not intended for any clinical use.

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