Sign in or Register   Sign in or Register
  |  

Rabbit Anti-CAMK1 Recombinant Antibody (BA0194) (CBMAB-0135CQ)

This product is a rabbit antibody that recognizes CAMK1. The antibody BA0194 can be used for immunoassay techniques such as: WB, IHC-P, ICC.
See all CAMK1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0194
Antibody Isotype
IgG
Application
WB, IHC-P, ICC

Basic Information

Immunogen
Peptide from residues on the N-terminus of human CaMKI
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
calcium/calmodulin-dependent protein kinase I
Introduction
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation.
Entrez Gene ID
Human8536
Mouse52163
Rat171503
UniProt ID
HumanQ14012
MouseQ91YS8
RatQ63450
Alternative Names
Calcium/Calmodulin-Dependent Protein Kinase I; CaM Kinase I Alpha; EC 2.7.11.17; CaMKI-Alpha; CaM-KI; CaM Kinase I; EC 2.7.11; CAMKI
Function
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x2-[ST]-x3-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca2+ elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity).

Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K+ and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.
Biological Process
Cell cycle Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Chemical synaptic transmission Source: Reactome
Negative regulation of protein binding Source: UniProtKB
Nervous system development Source: UniProtKB-KW
Nucleocytoplasmic transport Source: Ensembl
Peptidyl-serine phosphorylation Source: GO_Central
Positive regulation of dendritic spine development Source: UniProtKB
Positive regulation of muscle cell differentiation Source: BHF-UCL
Positive regulation of neuron projection development Source: UniProtKB
Positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
Positive regulation of protein acetylation Source: UniProtKB
Positive regulation of protein export from nucleus Source: UniProtKB
Positive regulation of protein serine/threonine kinase activity Source: UniProtKB
Positive regulation of synapse structural plasticity Source: UniProtKB
Positive regulation of syncytium formation by plasma membrane fusion Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of muscle cell differentiation Source: UniProtKB
Regulation of protein binding Source: UniProtKB
Regulation of protein localization Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Nucleus; Cytoplasm. Predominantly cytoplasmic.
PTM
Phosphorylated by CaMKK1 and CaMKK2 on Thr-177.
Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-CAMK1 Recombinant Antibody (BA0194)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare