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Mouse Anti-CARNMT1 Recombinant Antibody (4A2) (CBMAB-C6567-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Rat, Monkey, Dog
Clone
4A2
Antibody Isotype
IgG1
Application
FC, WB

Basic Information

Immunogen
Full length human recombinant protein of human C9orf41 produced in HEK293T cell.
Host Species
Mouse
Specificity
Human, Rat, Monkey, Dog
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
FC1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carnosine N-Methyltransferase 1
Introduction
The protein encoded by this gene is a methyltransferase that converts carnosine to anserine, a dipeptide found abundantly in skeletal muscle. The encoded protein can methylate other dipeptides as well. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Entrez Gene ID
138199
UniProt ID
Q8N4J0
Alternative Names
Carnosine N-Methyltransferase 1; C9orf41; Chromosome 9 Open Reading Frame 41; Carnosine N-Methyltransferase; UPF0586 Protein C9orf41; EC 2.1.1.22; UPF0586;
Function
N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
Biological Process
Carnosine metabolic process Source: UniProtKB
Histidine catabolic process Source: Reactome
Methylation Source: UniProtKB-KW
Cellular Location
Nucleus; Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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