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Mouse Anti-CASK Recombinant Antibody (CBYY-C0958) (CBMAB-C2395-YY)

This product is mouse antibody that recognizes CASK. The antibody CBYY-C0958 can be used for immunoassay techniques such as: WB, IF
See all CASK antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Dog, Frog, Human, Mouse
Clone
CBYY-C0958
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Rat CASK aa. 353-486
Specificity
Rat, Dog, Frog, Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
250 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcium/Calmodulin Dependent Serine Protein Kinase
Entrez Gene ID
Human8573
Mouse12361
Rat29647
Dog480887
Frog548958
UniProt ID
HumanO14936
MouseO70589
RatQ62915
DogE2RLG1
FrogF6UGQ3
Alternative Names
Caspase 8; Caspase 8, Apoptosis-Related Cysteine Peptidase; Caspase 8, Apoptosis-Related Cysteine Protease; MORT1-Associated Ced-3 Homolog; ICE-Like Apoptotic Protease 5; Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; FADD-Like ICE; Casp-8; FLICE; CAP4;
Function
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
Biological Process
Cell adhesion Source: ProtInc
Negative regulation of cell-matrix adhesion Source: BHF-UCL
Negative regulation of cellular response to growth factor stimulus Source: BHF-UCL
Negative regulation of keratinocyte proliferation Source: CACAO
Negative regulation of wound healing Source: BHF-UCL
Neurotransmitter transport Source: Reactome
Cellular Location
Cell membrane; Cytoplasm; Nucleus
Involvement in disease
Mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Affected individuals can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus.
FG syndrome 4 (FGS4): FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.

Pan, Y. E., Tibbe, D., Harms, F. L., Reißner, C., Becker, K., Dingmann, B., ... & Kreienkamp, H. J. (2021). Missense mutations in CASK, coding for the calcium‐/calmodulin‐dependent serine protein kinase, interfere with neurexin binding and neurexin‐induced oligomerization. Journal of Neurochemistry, 157(4), 1331-1350.

Zhang, K., Wang, T., Liu, X., Yuan, Q., Xiao, T., Yuan, X., ... & Wang, Y. (2021). CASK, APBA1, and STXBP1 collaborate during insulin secretion. Molecular and Cellular Endocrinology, 520, 111076.

Mustroph, J., Sag, C. M., Bähr, F., Schmidtmann, A. L., Gupta, S. N., Dietz, A., ... & Wagner, S. (2021). Loss of CASK Accelerates Heart Failure Development. Circulation research, 128(8), 1139-1155.

Tian, M., Pan, H., Lei, W., Chen, J., Li, J., Lang, C., & Shu, X. (2020). Calcium/Calmodulin-dependent Serine Protein Kinase-associated Neuro-gastrointestinal Disorder: First Report of a Patient With Hirschsprung‘s Disease. Journal of Neurogastroenterology and Motility, 26(4), 556.

Beuriot, A., Eichel, C. A., Dilanian, G., Louault, F., Melgari, D., Doisne, N., ... & Balse, E. (2020). Distinct calcium/calmodulin-dependent serine protein kinase domains control cardiac sodium channel membrane expression and focal adhesion anchoring. Heart rhythm, 17(5), 786-794.

Mori, T., Kasem, E. A., Suzuki-Kouyama, E., Cao, X., Li, X., Kurihara, T., ... & Tabuchi, K. (2019). Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by down-regulating GluN2B. Molecular psychiatry, 24(7), 1079-1092.

Seto, T., Hamazaki, T., Nishigaki, S., Kudo, S., Shintaku, H., Ondo, Y., ... & Yamamoto, T. (2017). A novel CASK mutation identified in siblings exhibiting developmental disorders with/without microcephaly. Intractable & rare diseases research, 6(3), 177-182.

Nafzger, S., & Rougier, J. S. (2017). Calcium/calmodulin-dependent serine protein kinase CASK modulates the L-type calcium current. Cell calcium, 61, 10-21.

Huang, T. N., & Hsueh, Y. P. (2017). Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice. Journal of psychiatry & neuroscience: JPN, 42(1), 37.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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