Human CASK ELISA Kit (V2LY-0626-LY5009)

Name: Human CASK ELISA Kit
SKU: V2LY-0626-LY5009
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0048 ng/mL

Detection Range

0.01-2 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

105.1 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Calcium/Calmodulin Dependent Serine Protein Kinase

Function

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).

Biological Process

Cell adhesion Source: ProtInc
Negative regulation of cell-matrix adhesion Source: BHF-UCL
Negative regulation of cellular response to growth factor stimulus Source: BHF-UCL
Negative regulation of keratinocyte proliferation Source: CACAO
Negative regulation of wound healing Source: BHF-UCL
Neurotransmitter transport Source: Reactome

Cellular Location

Cell membrane; Cytoplasm; Nucleus

Involvement in disease

Mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Affected individuals can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus.
FG syndrome 4 (FGS4): FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.

Pan, Y. E., Tibbe, D., Harms, F. L., Reißner, C., Becker, K., Dingmann, B., ... & Kreienkamp, H. J. (2021). Missense mutations in CASK, coding for the calcium‐/calmodulin‐dependent serine protein kinase, interfere with neurexin binding and neurexin‐induced oligomerization. Journal of Neurochemistry, 157(4), 1331-1350.

Zhang, K., Wang, T., Liu, X., Yuan, Q., Xiao, T., Yuan, X., ... & Wang, Y. (2021). CASK, APBA1, and STXBP1 collaborate during insulin secretion. Molecular and Cellular Endocrinology, 520, 111076.

Mustroph, J., Sag, C. M., Bähr, F., Schmidtmann, A. L., Gupta, S. N., Dietz, A., ... & Wagner, S. (2021). Loss of CASK Accelerates Heart Failure Development. Circulation research, 128(8), 1139-1155.

Tian, M., Pan, H., Lei, W., Chen, J., Li, J., Lang, C., & Shu, X. (2020). Calcium/Calmodulin-dependent Serine Protein Kinase-associated Neuro-gastrointestinal Disorder: First Report of a Patient With Hirschsprung‘s Disease. Journal of Neurogastroenterology and Motility, 26(4), 556.

Beuriot, A., Eichel, C. A., Dilanian, G., Louault, F., Melgari, D., Doisne, N., ... & Balse, E. (2020). Distinct calcium/calmodulin-dependent serine protein kinase domains control cardiac sodium channel membrane expression and focal adhesion anchoring. Heart rhythm, 17(5), 786-794.

Mori, T., Kasem, E. A., Suzuki-Kouyama, E., Cao, X., Li, X., Kurihara, T., ... & Tabuchi, K. (2019). Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by down-regulating GluN2B. Molecular psychiatry, 24(7), 1079-1092.

Seto, T., Hamazaki, T., Nishigaki, S., Kudo, S., Shintaku, H., Ondo, Y., ... & Yamamoto, T. (2017). A novel CASK mutation identified in siblings exhibiting developmental disorders with/without microcephaly. Intractable & rare diseases research, 6(3), 177-182.

Nafzger, S., & Rougier, J. S. (2017). Calcium/calmodulin-dependent serine protein kinase CASK modulates the L-type calcium current. Cell calcium, 61, 10-21.

Huang, T. N., & Hsueh, Y. P. (2017). Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice. Journal of psychiatry & neuroscience: JPN, 42(1), 37.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Cask ELISA Kit (CAT#: V2LY-0626-LY1893)

Human Recombinant CASK protein (CAT#: V2LY-0526-LY2594)

Human Recombinant CASK, Active protein, GST Tag (CAT#: V2LY-0526-LY2595)

Human Recombinant CASK protein, GST Tag (CAT#: V2LY-0526-LY2596)

Related Products

Mouse Anti-CASK Recombinant Antibody (0101) (CAT#: CBMAB-CP0101-LY)

Rat Cask ELISA Kit (CAT#: V2LY-0626-LY1893)

Mouse Anti-CASK Recombinant Antibody (0100) (CAT#: CBMAB-CP0100-LY)

Human Recombinant CASK protein, GST Tag (CAT#: V2LY-0526-LY2596)

Human Recombinant CASK protein (CAT#: V2LY-0526-LY2594)

Human Recombinant CASK, Active protein, GST Tag (CAT#: V2LY-0526-LY2595)

Mouse Anti-CASK Recombinant Antibody (S56A-50) (CAT#: CBMAB-C9721-LY)

Mouse Anti-CASK Recombinant Antibody (CBYY-C0958) (CAT#: CBMAB-C2395-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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