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Rat Anti-CASP12 (AA 183-205) Recombinant Antibody (CBFYC-0825) (CBMAB-C0880-FY)

This product is rat antibody that recognizes CASP12. The antibody CBFYC-0825 can be used for immunoassay techniques such as: ELISA, FC, WB.
See all CASP12 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYC-0825
Antibody Isotype
IgG1
Application
ELISA, FC, WB

Basic Information

Immunogen
Recombinant mouse caspase-12 (p20 fragment) and synthetic peptide corresponding to aa 183-205 of mouse caspase-12
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
>95% by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 183-205

Target

Full Name
Caspase 12 (Gene/Pseudogene)
Introduction
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
Entrez Gene ID
12364
UniProt ID
O08736
Alternative Names
caspase-12; CASP-12
Function
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Biological Process
Execution phase of apoptosis Source: GOC
Regulation of apoptotic process Source: InterPro
Regulation of inflammatory response Source: GO_Central
Cellular Location
AIM2 inflammasome complex; IPAF inflammasome complex; NLRP3 inflammasome complex; Endoplasmic reticulum; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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