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Rabbit Anti-CASP5 Recombinant Antibody (CBLC117-LY) (CBMAB-C9738-LY)

The product is antibody recognizes CASP5. The antibody CBLC117-LY immunoassay techniques such as: WB, IP.
See all CASP5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBLC117-LY
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Primary
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Caspase 5
Introduction
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
Entrez Gene ID
838
UniProt ID
P51878
Alternative Names
Caspase 5; Caspase 5, Apoptosis-Related Cysteine Peptidase; Caspase 5, Apoptosis-Related Cysteine Protease; Protease ICH-3; Protease TY; ICE(Rel)-III; EC 3.4.22.58; TY Protease;
Function
Thiol protease that acts as a mediator of programmed cell death (PubMed:29898893, PubMed:28314590).
Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (PubMed:29898893).
During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).
Biological Process
Apoptotic process Source: ProtInc
Cellular response to mechanical stimulus Source: UniProtKB
Execution phase of apoptosis Source: GOC
Proteolysis Source: ProtInc
Regulation of apoptotic process Source: InterPro
Regulation of inflammatory response Source: GO_Central
Substantia nigra development Source: UniProtKB
Cellular Location
NLRP1 inflammasome complex; Cytoplasm
PTM
The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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