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Rat Anti-CBFA2T2 Recombinant Antibody (CBFYM-0896) (CBMAB-M1044-FY)

This product is rat antibody that recognizes CBFA2T2. The antibody CBFYM-0896 can be used for immunoassay techniques such as: WB, IP.
See all CBFA2T2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYM-0896
Antibody Isotype
IgG2c
Application
WB, IP

Basic Information

Immunogen
Synthetic peptide encompassing a sequence within mouse MTGR1 protein coupled to BSA
Specificity
Mouse
Antibody Isotype
IgG2c
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CBFA2/RUNX1 Translocation Partner 2
Introduction
Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.
Entrez Gene ID
12396
UniProt ID
O70374
Alternative Names
MTGR1; Cbfa2t2h; A430091M07; C330013D05Rik
Function
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199).
Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218).
Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity).
Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453).
May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity).
Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity).
Biological Process
Intestinal epithelial cell differentiation Source: Ensembl
Negative regulation of neuron projection development Source: UniProtKB
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of neuron projection development Source: UniProtKB
Transcription, DNA-templated Source: InterPro
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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