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CBFA2T2 Matched Antibody Pair (187) (APMAB-187LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-CBFA2T2 monoclonal, IgG2a antibody, 100 ug
Detection Antibody
Anti-CBFA2T2 Biotinylated mouse monoclonal, IgG2a antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Alternative Names
CBFA2/RUNX1 Translocation Partner 2; Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 2; Myeloid Translocation-Related Protein 1; ETO Homologous On Chromosome 20; MTG8-Related Protein 1; MTG8-Like Protein; MTGR1;
Entrez Gene ID
9139
UniProt ID
O43439
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For research use only. Not intended for any clinical use.

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