Sign in or Register   Sign in or Register
  |  

Mouse Anti-CBFA2T3 Recombinant Antibody (CBFYC-0881) (CBMAB-C0936-FY)

This product is mouse antibody that recognizes CBFA2T3. The antibody CBFYC-0881 can be used for immunoassay techniques such as: WB.
See all CBFA2T3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0881
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CBFA2/RUNX1 TRANSLOCATION PARTNER 3
Introduction
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
Entrez Gene ID
863
UniProt ID
O75081
Alternative Names
CBFA2/RUNX1 Translocation Partner 3; Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 3; Myeloid Translocation Gene On Chromosome 16 Protein; Zinc Finger MYND Domain-Containing Protein 4; Myeloid Translocation Gene 8 And 16b; MTG8-Related Protein 2; ZMYND4; MTG16
Function
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199).
Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453).
Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097).
Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097).
Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity).
Plays a role in granulocyte differentiation (PubMed:15231665).
Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486).
Biological Process
Granulocyte differentiation Source: MGI
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of glycolytic process Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Regulation of aerobic respiration Source: UniProtKB
Response to hypoxia Source: UniProtKB
Transcription, DNA-templated Source: InterPro
Cellular Location
Isoform 1: Nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.
Isoform 2: Golgi apparatus membrane; Nucleoplasm
Involvement in disease
A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CBFA2T3 Recombinant Antibody (CBFYC-0881)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare