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Mouse Anti-CBFA2T3 Recombinant Antibody (CBFYE-1338) (CBMAB-E1947-FY)

This product is mouse antibody that recognizes CBFA2T3. The antibody CBFYE-1338 can be used for immunoassay techniques such as: WB, IP, IF, IHC-P, ELISA.
See all CBFA2T3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYE-1338
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CBFA2/RUNX1 TRANSLOCATION PARTNER 3
Introduction
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression.
Entrez Gene ID
Human863
Mouse12398
Rat361431
UniProt ID
HumanO75081
MouseB7ZP57
RatD4A303
Alternative Names
ETO2; MTG16; MTGR2; ZMYND4; RUNX1T3
Function
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199).
Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453).
Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097).
Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097).
Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity).
Plays a role in granulocyte differentiation (PubMed:15231665).
Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486).
Biological Process
Granulocyte differentiation Source: MGI
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of glycolytic process Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Regulation of aerobic respiration Source: UniProtKB
Response to hypoxia Source: UniProtKB
Transcription, DNA-templated Source: InterPro
Cellular Location
Isoform 1: Nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.
Isoform 2: Golgi apparatus membrane; Nucleoplasm
Involvement in disease
A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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