Mouse Anti-CBLL1 Recombinant Antibody (CBLC129-LY) (CBMAB-C9776-LY)

Name: Mouse Anti-CBLL1 Recombinant Antibody (CBLC129-LY)
SKU: CBMAB-C9776-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLC129-LY

Application

WB, IF, ELISA

Immunogen

CBLL1 (1 a.a. ~ 100 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IF(ICC)	10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1

Introduction

This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]

Entrez Gene ID

79872

UniProt ID

Q75N03

Alternative Names

Cbl Proto-Oncogene Like 1; Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1; Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1; Cbl Proto-Oncogene Like 1, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase Hakai; RING Finger Protein 188; C-Cbl-Like Protein 1; RNF188; HAKAI;

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity).
Targets CDH1 for endocytosis and degradation (By similarity).
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755).
Its function in the WMM complex is unknown (PubMed:29507755).

Biological Process

Cell-cell adhesion Source: UniProtKB
Entry of bacterium into host cell Source: Reactome
mRNA methylation Source: UniProtKB
Multicellular organism development Source: UniProtKB-KW
Negative regulation of cell adhesion Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of endocytosis Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of cell adhesion Source: GO_Central

Cellular Location

Cytoplasm; Nucleus speckle; Nucleoplasm. Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.

PTM

Phosphorylated on tyrosine residues.

Mamoor, S. (2021). CBLL1 is differentially expressed in lymph node metastasis in human breast cancer.

Li, H., Liu, F., & Qin, W. (2020). Circ_0072083 interference enhances growth-inhibiting effects of cisplatin in non-small-cell lung cancer cells via miR-545-3p/CBLL1 axis. Cancer cell international, 20(1), 1-13.

Guo, Q., Li, D., Ji, Y. M., & Guo, J. (2020). The Role of M6A-related CBLL1 in the Prognosis and Immune Infiltration of Pan-cancer.

Hui, L., Zhang, S., Wudu, M., Ren, H., Xu, Y., Zhang, Q., & Qiu, X. (2019). CBLL1 is highly expressed in non‐small cell lung cancer and promotes cell proliferation and invasion. Thoracic cancer, 10(6), 1479-1488.

Qiu, H. B., Yang, K., Yu, H. Y., & Liu, M. (2019). Downregulation of long non-coding RNA XIST inhibits cell proliferation, migration, invasion and EMT by regulating miR-212-3p/CBLL1 axis in non-small cell lung cancer cells. Eur Rev Med Pharmacol Sci, 23(19), 8391-8402.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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