CBLL1

Epithelial cell cadherin (CDH1; MIM 192090) is endocytosed as a consequence of tyrosine phosphorylation and ubiquitination. HAKAI is an E3 ubiquitin ligase (see UBE3A; MIM 601623) that mediates ubiquitination of the CDH1 complex.[supplied by OMIM

Full Name

Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity).
Targets CDH1 for endocytosis and degradation (By similarity).
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755).
Its function in the WMM complex is unknown (PubMed:29507755).

Biological Process

Cell-cell adhesion Source: UniProtKB
Entry of bacterium into host cell Source: Reactome
mRNA methylation Source: UniProtKB
Multicellular organism development Source: UniProtKB-KW
Negative regulation of cell adhesion Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of endocytosis Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of cell adhesion Source: GO_Central

Cellular Location

Cytoplasm; Nucleus speckle; Nucleoplasm. Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.

PTM

Phosphorylated on tyrosine residues.