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Mouse Anti-CBX7 Recombinant Antibody (CBLC131-LY) (CBMAB-C9785-LY)

The product is antibody recognizes CBX7. The antibody CBLC131-LY immunoassay techniques such as: WB, IP, IF, ELISA.
See all CBX7 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBLC131-LY
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chromobox 7
Introduction
This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]
Entrez Gene ID
52609
UniProt ID
Q8VDS3
Alternative Names
1600014J01Rik, AI851678, D15Ertd417e
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Biological Process
Chromatin organization Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus

Huang, Z., Yan, Y., Zhu, Z., Liu, J., He, X., Dalangood, S., ... & Yan, J. (2021). CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10–ERK signaling. Cell death & disease, 12(6), 1-15.

Zhang, H. T., Wang, X. Z., Zhang, Q. M., & Zhao, H. (2021). Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway. Human & Experimental Toxicology, 09603271211036122.

Zhang, Y., Zhang, J. J., Liu, X. H., & Wang, L. (2020). CBX7 suppression prevents ischemia-reperfusion injury-induced endoplasmic reticulum stress through the Nrf-2/HO-1 pathway. American Journal of Physiology-Renal Physiology, 318(6), F1531-F1538.

Mamoor, S. (2020). CBX7 is differentially expressed in high-grade serous ovarian cancers.

Federico, A., Sepe, R., Cozzolino, F., Piccolo, C., Iannone, C., Iacobucci, I., ... & Fusco, A. (2019). The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1862(4), 509-521.

Li, R., Yan, Q., Tian, P., Wang, Y., Wang, J., Tao, N., ... & Ma, C. (2019). CBX7 inhibits cell growth and motility and induces apoptosis in cervical cancer cells. Molecular Therapy-Oncolytics, 15, 108-116.

Ni, S. J., Zhao, L. Q., Wang, X. F., Wu, Z. H., Hua, R. X., Wan, C. H., ... & Guo, W. J. (2018). CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways. Journal of hematology & oncology, 11(1), 1-14.

Yongyu, Z., Lewei, Y., Jian, L., & Yuqin, S. (2018). MicroRNA-18a targets IRF2 and CBX7 to promote cell proliferation in hepatocellular carcinoma. Oncology research, 26(9), 1327.

Traoré, M., Gignac, M., Doan, N. D., Hof, F., & Lubell, W. D. (2017). Aza‐amino acid scanning of chromobox homolog 7 (CBX7) ligands. Journal of Peptide Science, 23(4), 266-271.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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