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Mouse Anti-CBX7 Recombinant Antibody (CBT3890) (V2LY-0625-LY644)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3890
Antibody Isotype
IgG1
Application
ICC

Basic Information

Immunogen
Purified recombinant fragment of human CBX7 (AA: 15-147) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:50-1:200
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chromobox 7
Entrez Gene ID
23492
UniProt ID
O95931
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Biological Process
Chromatin organization Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus
More Infomation

Huang, Z., Yan, Y., Zhu, Z., Liu, J., He, X., Dalangood, S., ... & Yan, J. (2021). CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10–ERK signaling. Cell death & disease, 12(6), 1-15.

Zhang, H. T., Wang, X. Z., Zhang, Q. M., & Zhao, H. (2021). Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway. Human & Experimental Toxicology, 09603271211036122.

Zhang, Y., Zhang, J. J., Liu, X. H., & Wang, L. (2020). CBX7 suppression prevents ischemia-reperfusion injury-induced endoplasmic reticulum stress through the Nrf-2/HO-1 pathway. American Journal of Physiology-Renal Physiology, 318(6), F1531-F1538.

Mamoor, S. (2020). CBX7 is differentially expressed in high-grade serous ovarian cancers.

Federico, A., Sepe, R., Cozzolino, F., Piccolo, C., Iannone, C., Iacobucci, I., ... & Fusco, A. (2019). The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1862(4), 509-521.

Li, R., Yan, Q., Tian, P., Wang, Y., Wang, J., Tao, N., ... & Ma, C. (2019). CBX7 inhibits cell growth and motility and induces apoptosis in cervical cancer cells. Molecular Therapy-Oncolytics, 15, 108-116.

Ni, S. J., Zhao, L. Q., Wang, X. F., Wu, Z. H., Hua, R. X., Wan, C. H., ... & Guo, W. J. (2018). CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways. Journal of hematology & oncology, 11(1), 1-14.

Yongyu, Z., Lewei, Y., Jian, L., & Yuqin, S. (2018). MicroRNA-18a targets IRF2 and CBX7 to promote cell proliferation in hepatocellular carcinoma. Oncology research, 26(9), 1327.

Traoré, M., Gignac, M., Doan, N. D., Hof, F., & Lubell, W. D. (2017). Aza‐amino acid scanning of chromobox homolog 7 (CBX7) ligands. Journal of Peptide Science, 23(4), 266-271.

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For research use only. Not intended for any clinical use.

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