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Rabbit Anti-CBX8 Recombinant Antibody (CBFYC-0906) (CBMAB-C0962-FY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYC-0906
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Immunogen
Protein corresponding to human CBX8 (aa81-aa281).
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)1:100
WB1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-260

Target

Full Name
Chromobox 8
Introduction
CBX8 (Chromobox 8) is a Protein Coding gene. Diseases associated with CBX8 include Conversion Disorder. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and single-stranded RNA binding. An important paralog of this gene is CBX6.
Entrez Gene ID
57332
UniProt ID
Q9HC52
Alternative Names
Chromobox 8; Rectachrome 1; Polycomb 3; PC3; RC1; Chromobox Homolog 8 (Pc Class Homolog, Drosophila); Chromobox Homolog 8 (Drosophila Pc Class)
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Biological Process
Cellular response to hydrogen peroxide Source: Ensembl
Histone ubiquitination Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of collagen biosynthetic process Source: Ensembl
Positive regulation of DNA repair Source: Ensembl
Cellular Location
Nucleus
More Infomation

Liang, Y., Yu, Z. J., Liu, M., Liu, H. M., Zhang, J. Z., Xiong, T., ... & Huang, Z. P. (2021). hsa‑miR‑429 targets CBX8 to promote cell apoptosis in diffuse large B‑cell lymphoma. Molecular Medicine Reports, 24(6), 1-8.

Zeng, F., Luo, L., Li, D., Guo, J., & Guo, M. (2021). KPNA2 interaction with CBX8 contributes to the development and progression of bladder cancer by mediating the PRDM1/c-FOS pathway. Journal of Translational Medicine, 19(1), 1-15.

Kim, H. J., Park, J. W., Kang, J. Y., & Seo, S. B. (2021). Negative Regulation of Erythroid Differentiation via the CBX8-TRIM28 Axis. Molecules and Cells, 44(7), 444.

Zhou, H., Li, A., Li, C., Wu, M., Jin, D., & Shui, M. (2021). The co-expression of CBX8 and PD-L1 and prognostic value in cervical cancer. Medicine, 100(34), e27056.

Zhu, X., Luo, W., Bei, C., Kong, J., Zhang, S., Fu, Y., ... & Tan, S. (2019). RETRACTED ARTICLE: Correlations between chromobox homolog 8 and key factors of epithelial–mesenchymal transition in hepatocellular carcinoma. Cancer cell international, 19(1), 1-9.

Tang, B., Tian, Y., Liao, Y., Li, Z., Yu, S., Su, H., ... & He, S. (2019). CBX8 exhibits oncogenic properties and serves as a prognostic factor in hepatocellular carcinoma. Cell death & disease, 10(2), 1-14.

Xiao, L., Zhou, Z., Li, W., Peng, J., Sun, Q., Zhu, H., ... & Liu, L. (2019). Chromobox homolog 8 (CBX8) Interacts with Y-Box binding protein 1 (YBX1) to promote cellular proliferation in hepatocellular carcinoma cells. Aging (Albany NY), 11(17), 7123.

Zhang, Y., Chen, H., Zhu, H., & Sun, X. (2019). CBX8 promotes tumorigenesis and confers radioresistance in esophageal squamous cell carcinoma cells through targeting APAF1. Gene, 711, 143949.

Zhang, C. Z., Chen, S. L., Wang, C. H., He, Y. F., Yang, X., Xie, D., & Yun, J. P. (2018). CBX8 exhibits oncogenic activity via AKT/β-catenin activation in hepatocellular carcinoma. Cancer research, 78(1), 51-63.

Yuan, G. J., Chen, X., Lu, J., Feng, Z. H., Chen, S. L., Chen, R. X., ... & Xie, D. (2017). Chromobox homolog 8 is a predictor of muscle invasive bladder cancer and promotes cell proliferation by repressing the p53 pathway. Cancer science, 108(11), 2166-2175.

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For research use only. Not intended for any clinical use.

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