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CBX8

CBX8 (Chromobox 8) is a Protein Coding gene. Diseases associated with CBX8 include Conversion Disorder. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and single-stranded RNA binding. An important paralog of this gene is CBX6.

Full Name

Chromobox 8

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Biological Process

Cellular response to hydrogen peroxide Source: Ensembl
Histone ubiquitination Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of collagen biosynthetic process Source: Ensembl
Positive regulation of DNA repair Source: Ensembl

Cellular Location

Nucleus

Anti-CBX8 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Rabbit Anti-CBX8 Recombinant Antibody (D2O8C) (CBMAB-CP0155-LY)

SDS

Target: CBX8

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D2O8C

Application*: WB, IP

Mouse Anti-CBX8 Recombinant Antibody (CBYY-C1042) (CBMAB-C2479-YY)

SDS

Target: CBX8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1042

Application*: E, WB, F

Mouse Anti-CBX8 Recombinant Antibody (1C7) (CBMAB-C3763-LY)

SDS

Target: CBX8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 1C7

Application*: WB

Mouse Anti-CBX8 Recombinant Antibody (121E2C) (CBMAB-C2574-LY)

SDS

Target: CBX8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 121E2C

Application*: F, WB

Rabbit Anti-CBX8 Recombinant Antibody (CBFYC-0906) (CBMAB-C0962-FY)

SDS

Target: CBX8

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-0906

Application*: WB, IF

Mouse Anti-CBX8 Recombinant Antibody (CBFYC-0904) (CBMAB-C0960-FY)

SDS

Target: CBX8

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-0904

Application*: IH, F, WB

Mouse Anti-CBX8 Recombinant Antibody (CBFYC-0903) (CBMAB-C0959-FY)

SDS

Target: CBX8

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: CBFYC-0903

Application*: WB, IP, IF, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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