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Mouse Anti-CCKAR Recombinant Antibody (CBYY-C2748) (CBMAB-C4189-YY)

This product is mouse antibody that recognizes CCKAR. The antibody CBYY-C2748 can be used for immunoassay techniques such as: FC
See all CCKAR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2748
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Recombinant corresponding to human Cholecystokinin A Receptor expressed in NSO cells (NP_000721). Species sequence homology: Mouse, rat 89%
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Buffer
0.5 mg/mL
Preservative
PBS, 5% trehalose
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cholecystokinin A Receptor
Entrez Gene ID
886
UniProt ID
P32238
Alternative Names
Integrin Subunit Beta 2
Function
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Biological Process
Axonogenesis Source: Ensembl
Cholecystokinin signaling pathway Source: GO_Central
Forebrain development Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Neuron migration Source: Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of hormone secretion Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-41
Helical: 42-67
Cytoplasmic: 68-77
Helical: 78-104
Extracellular: 105-115
Helical: 116-137
Cytoplasmic: 138-157
Helical: 158-178
Extracellular: 179-210
Helical: 211-234
Cytoplasmic: 235-313
Helical: 314-334
Extracellular: 335-349
Helical: 350-373
Cytoplasmic: 374-428

Pangniban, R., Sun, M., Park, C. Y., Koh, A., Kasahara, D., Israel, E., ... & Lu, Q. (2021). Antagonizing the metabolic hormone cholecystokinin (CCK) and its receptor CCKAR in the lung abolishes obesity-induced airway hyperresponsiveness.

Wang, H. H., Portincasa, P., Liu, M., Tso, P., & Wang, D. Q. H. (2020). An Update on the Lithogenic Mechanisms of Cholecystokinin a Receptor (CCKAR), an Important Gallstone Gene for Lith13. Genes, 11(12), 1438.

Rikimaru, K., Sato, Y., Ito, Y., Fukuda, S., Sasaki, S., & Takahashi, H. (2020). Is a single nucleotide Polymorphism marker in the cholecystokinin A receptor gene practically suitable for improving the growth traits of Hinai-jidori chickens?. The Journal of Poultry Science, 57(2), 99-106.

Kim, H. T., Sacotte, S., Williams, R. A., De Souza, A. H., Han, J. Y., Bartosiak, J. T., ... & Davis, D. B. (2019). 2137-P: Cholecystokinin Protects Mouse Pancreatic Beta Cells against Cytokine Insult through the Cholecystokinin A Receptor.

Panganiban, R. A. M., Sun, M., Park, C. Y., Kasahara, D. I., Himes, B. E., Israel, E., ... & Lu, Q. (2018). Targeting cholecystokinin (CCK) and its receptor CCKAR in the airway smooth muscle for new asthma therapy. In B20. ASTHMA: NEW FINDINGS IN AIRWAY SMOOTH MUSCLE PATHOPHYSIOLOGY AND POTENTIAL THERAPY (pp. A2744-A2744). American Thoracic Society.

Yi, Z., Li, X., Luo, W., Xu, Z., Ji, C., Zhang, Y., ... & Zhang, X. (2018). Feed conversion ratio, residual feed intake and cholecystokinin type A receptor gene polymorphisms are associated with feed intake and average daily gain in a Chinese local chicken population. Journal of animal science and biotechnology, 9(1), 1-9.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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