CCKAR

CCKAR (Cholecystokinin A Receptor) is a Protein Coding gene. Diseases associated with CCKAR include Panic Disorder and Dyspepsia. Among its related pathways are Peptide ligand-binding receptors and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and cholecystokinin receptor activity. An important paralog of this gene is CCKBR.

Full Name

Cholecystokinin A Receptor

Function

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Biological Process

Axonogenesis Source: Ensembl
Cholecystokinin signaling pathway Source: GO_Central
Forebrain development Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Neuron migration Source: Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of hormone secretion Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-41
Helical: 42-67
Cytoplasmic: 68-77
Helical: 78-104
Extracellular: 105-115
Helical: 116-137
Cytoplasmic: 138-157
Helical: 158-178
Extracellular: 179-210
Helical: 211-234
Cytoplasmic: 235-313
Helical: 314-334
Extracellular: 335-349
Helical: 350-373
Cytoplasmic: 374-428