Rabbit Anti-CCL14 Recombinant Antibody (015) (CBMAB-C1625-LY)

Name: Rabbit Anti-CCL14 Recombinant Antibody (015)
SKU: CBMAB-C1625-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

015

Application

ELISA

Immunogen

Recombinant Human CCL14 Protein.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

chemokine (C-C motif) ligand 14

Introduction

CCL14 (C-C Motif Chemokine Ligand 14) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL3.

Entrez Gene ID

6358

UniProt ID

Q16627

Alternative Names

C-C Motif Chemokine Ligand 14; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 14; Chemokine (C-C Motif) Ligand 14; Small-Inducible Cytokine A14; Chemokine CC-1/CC-3; HCC-1(1-74); HCC-1/HCC-3; SCYA14; NCC-2; NCC2; Hemofiltrate CC Chemokine 1; C-C Motif Chemokine 14;

Function

Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

Biological Process

Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central

Cellular Location

Secreted

PTM

The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.

Massoth, C., Küllmar, M., Enders, D., Kellum, J. A., Forni, L. G., Meersch, M., ... & Rossaint, J. (2021). Comparison of CC motif chemokine ligand 14 with other biomarkers for adverse kidney events after cardiac surgery. The Journal of Thoracic and Cardiovascular Surgery.

Li, N., Liang, X., Li, J., Zhang, D., Li, T., & Guo, Z. (2021). CC motif chemokine ligand 14 inhibited colon cancer cell proliferation and invasion through suppressing M2 polarization of tumor-associated macrophages. Histology and Histopathology, 18348-18348.

Bagshaw, S. M., Al-Khafaji, A., Artigas, A., Davison, D., Haase, M., Lissauer, M., ... & Kellum, J. A. (2021). External validation of urinary C–C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury. Critical Care, 25(1), 1-8.

Yan, G., Li, S., Yue, M., Li, C., & Kang, Z. (2021). Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/β-catenin pathway. Life Sciences, 264, 118726.

Mamoor, S. (2021). Differential expression of CCL14 in cancer of the vulva.

Gu, Y., Li, X., Bi, Y., Zheng, Y., Wang, J., Li, X., ... & Huang, Y. (2020). CCL14 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma. Aging (Albany NY), 12(1), 784.

Cai, Y., Ling, Y., Huang, L., Huang, H., Chen, X., Xiao, Y., ... & Chen, J. (2020). C‑C motif chemokine 14 as a novel potential biomarker for predicting the prognosis of epithelial ovarian cancer. Oncology letters, 19(4), 2875-2883.

Zhu, M., Xu, W., Wei, C., Huang, J., Xu, J., Zhang, Y., ... & Liang, C. (2019). CCL14 serves as a novel prognostic factor and tumor suppressor of HCC by modulating cell cycle and promoting apoptosis. Cell death & disease, 10(11), 1-10.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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