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CCL14

This gene, CCL14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene CCL15, and are represented as GeneID: 348249. [provided by RefSeq]
Full Name
chemokine (C-C motif) ligand 14
Function
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
Biological Process
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Cellular Location
Secreted
PTM
The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.
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Anti-CCL14 antibodies

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Mouse Anti-CCL14 Recombinant Antibody (CBXS-0010) (CBMAB-S3015-CQ)

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Target: CCL14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0010
Application*: E
Datasheet SDS

Mouse Anti-CCL14 Recombinant Antibody (CBXC-1991) (CBMAB-C5407-CQ)

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Target: CCL14
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-1991
Application*: E
Datasheet SDS

Mouse Anti-CCL14 Recombinant Antibody (CBYY-C1059) (CBMAB-C2496-YY)

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Target: CCL14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1059
Application*: E
Datasheet SDS

Rabbit Anti-CCL14 Recombinant Antibody (CBFYC-0930) (CBMAB-C0986-FY)

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Target: CCL14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0930
Application*: E
Datasheet SDS

Rat Anti-CCL14 Recombinant Antibody (CBFYC-0928) (CBMAB-C0984-FY)

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Target: CCL14
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-0928
Application*: WB
Datasheet SDS

Rat Anti-CCL14 Recombinant Antibody (4H14) (CBMAB-C7025-LY)

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Target: CCL14
Host: Rat
Antibody Isotype: IgG2
Specificity: Human
Clone: 4H14
Application*: N, WB
Functional Assay
Datasheet SDS

Mouse Anti-CCL14 Recombinant Antibody (C5693) (CBMAB-C5693-LY)

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Target: CCL14
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: C5693
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-CCL14 Recombinant Antibody (1F12) (CBMAB-C4021-LY)

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Target: CCL14
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1F12
Application*: E, WB
Datasheet SDS

Mouse Anti-CCL14 Recombinant Antibody (C3189) (CBMAB-C3189-LY)

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Target: CCL14
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C3189
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-CCL14 Recombinant Antibody (015) (CBMAB-C1625-LY)

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Target: CCL14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 015
Application*: E
Datasheet SDS

Mouse Anti-CCL14 Recombinant Antibody (C0744) (CBMAB-C0744-LY)

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Target: CCL14
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C0744
Application*: WB, IP, IF, E, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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