Rat Anti-CCL6 Recombinant Antibody (11D7) (CBMAB-C2506-LY)

This product is antibody recognizes CCL6. The antibody 11D7 immunoassay techniques such as: ELISA.
See all CCL6 antibodies

Datasheet

Summary

Host Animal

Rat

Specificity

Mouse

Clone

11D7

Antibody Isotype

IgG2

Application

ELISA

Basic Information

Immunogen

Mouse recombinant protein CCL-6

Specificity

Mouse

Antibody Isotype

IgG2

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

chemokine (C-C motif) ligand 6

Entrez Gene ID

20305

UniProt ID

P27784

Function

CCL6(22-95) and CCL6(23-95) are potent chemoattractants.

Biological Process

Cell chemotaxis Source: MGI
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central

Cellular Location

Secreted

References

Li, F., Du, X., Lan, F., Li, N., Zhang, C., Zhu, C., ... & Shen, H. (2021). Eosinophilic inflammation promotes CCL6-dependent metastatic tumor growth. Science Advances, 7(22), eabb5943.

Li, X., Aishan, B., Yang, Y., Xie, Y., Lati, D., & Tuerxun, P. (2020). Chemokine (CC motif) Ligand 6 Aggravates Hypoxia Reoxygenation–induced Apoptosis in H9c2 Cells Through Enhancing the Expression of Insulin-like Growth Factor 2-Antisense. Journal of Cardiovascular Pharmacology, 76(5), 549-555.

Du, X., Li, F., Li, N., Shao, Z., Zhang, C., Huang, H., ... & Shen, H. (2020). Eosinophil-Derived Chemokine CCL6 Promote Allergic Airway Inflammation. In D91. EOSINOPHILS IN ASTHMA, PATHOPHYSIOLOGICAL AND CLINICAL IMPLICATIONS (pp. A7630-A7630). American Thoracic Society.

Du, X., Li, F., Shao, Z., Zhang, C., Li, W., Chen, Z., ... & Shen, H. (2019). CCL6 produced by eosinophils drives allergic airway inflammation in mice.

Zhang, C., Yi, W., Li, F., Du, X., Wang, H., Wu, P., ... & Shen, H. (2018). Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis. Cell research, 28(3), 323-335.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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