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Rat Anti-CCN3 Recombinant Antibody (CBYY-C1101) (CBMAB-C2538-YY)

This product is rat antibody that recognizes CCN3. The antibody CBYY-C1101 can be used for immunoassay techniques such as: WB
See all CCN3 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-C1101
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Mouse recombinant protein of NOV
Specificity
Mouse
Antibody Isotype
IgG2
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Preservative
PBS
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CCN3
Entrez Gene ID
18133
UniProt ID
Q64299
Alternative Names
C-C Motif Chemokine Receptor 1; Macrophage Inflammatory Protein 1-Alpha Receptor; Chemokine (C-C Motif) Receptor 1; LD78 Receptor; MIP-1alpha-R; C-C CKR-1; CC-CKR-1; RANTES-R; CMKBR1; SCYAR1; CCR-1;
Function
Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162).
Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078).
Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287).
Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162).
Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355).
Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522).
Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078).
Involved in bone regeneration as a negative regulator (By similarity).
Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891).
Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity).
Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504).
Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity).
Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).
Biological Process
Angiogenesis Source: UniProtKB
Bone regeneration Source: UniProtKB
Cell adhesion Source: GO_Central
Cell adhesion mediated by integrin Source: UniProtKB
Cell chemotaxis Source: UniProtKB
Chondrocyte differentiation Source: UniProtKB
Endothelial cell-cell adhesion Source: UniProtKB
Endothelial cell chemotaxis Source: UniProtKB
Fibroblast migration Source: UniProtKB
Hematopoietic stem cell homeostasis Source: UniProtKB
Negative regulation of cell death Source: GO_Central
Negative regulation of cell growth Source: UniProtKB
Negative regulation of chondrocyte proliferation Source: UniProtKB
Negative regulation of inflammatory response Source: UniProtKB
Negative regulation of insulin secretion Source: UniProtKB
Negative regulation of monocyte chemotaxis Source: UniProtKB
Negative regulation of myotube differentiation Source: UniProtKB
Negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
Negative regulation of sensory perception of pain Source: UniProtKB
Negative regulation of SMAD protein signal transduction Source: UniProtKB
Positive regulation of Notch signaling pathway Source: UniProtKB
Regulation of gene expression Source: Ensembl
Signal transduction Source: GO_Central
Smooth muscle cell migration Source: UniProtKB
Smooth muscle cell proliferation Source: UniProtKB
Type B pancreatic cell proliferation Source: UniProtKB
Cellular Location
Cytoplasm; Secreted; Gap junction. Localizes at the gap junction in presence of GJA1.
PTM
May be palmitoylated on Cys-244, which is important for extracellular secretion.

Kubota, S., Kawaki, H., Perbal, B., Kawata, K., Hattori, T., & Nishida, T. (2021). Cellular communication network factor 3 in cartilage development and maintenance. Journal of Cell Communication and Signaling, 1-11.

Mizukawa, T., Nishida, T., Akashi, S., Kawata, K., Kikuchi, S., Kawaki, H., ... & Kubota, S. (2021). RFX1‐mediated CCN3 induction that may support chondrocyte survival under starved conditions. Journal of cellular physiology.

Wang, H., Huang, B., Hou, A., Xue, L., Wang, B., Chen, J., ... & Zhang, J. V. (2021). High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway. American Journal of Physiology-Endocrinology and Metabolism, 320(4), E786-E796.

Chen, R., Masuo, K., Yogo, A., Yokoyama, S., Sugiyama, A., Seno, H., ... & Takaishi, S. (2021). SNAIL regulates gastric carcinogenesis through CCN3 and NEFL. Carcinogenesis, 42(2), 190-201.

Kuwahara, M., Kadoya, K., Kondo, S., Fu, S., Miyake, Y., Ogo, A., ... & Hattori, T. (2020). CCN3 (NOV) drives degradative changes in aging articular cartilage. International journal of molecular sciences, 21(20), 7556.

Naughton, M., Moffat, J., Eleftheriadis, G., de la Vega Gallardo, N., Young, A., Falconer, J., ... & Fitzgerald, D. C. (2020). CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis. Journal of neuroinflammation, 17(1), 1-13.

Li, H., Ge, X., Pan, K., Sui, M., Cai, H., Cui, C., ... & Lu, S. (2019). The Predictive Role of Tenascin-C and Cellular Communication Network Factor 3 (CCN3) in Post Hepatectomy Liver Failure in a Rat Model and 50 Patients Following Partial Hepatectomy. Medical science monitor: international medical journal of experimental and clinical research, 25, 6755.

Vatanmakanian, M., Tavallaie, M., & Ghadami, S. (2019). Imatinib independent aberrant methylation of NOV/CCN3 in chronic myelogenous leukemia patients: a mechanism upstream of BCR-ABL1 function?. Cell Communication and Signaling, 17(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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